Articles: extravascular-lung-water.
-
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Oct 2009
Randomized Controlled Trial[A study on the effect of recruitment maneuver imposed on extravascular lung water in patients with acute respiratory distress syndrome].
To investigate the possible effects of recruitment maneuver (RM) imposing on extravascular lung water (EVLW) in patients with acute respiratory distress syndrome (ARDS). ⋯ RM for the patients with ARDS can merely improve lung mechanics without obvious effect on EVLW. Neither of the influencing factors involved in the study has impact on emergence and clearance of EVLW.
-
Randomized Controlled Trial
Effects of epidural anesthesia on intrathoracic blood volume and extravascular lung water during on-pump cardiac surgery.
The most important side effect of epidural anesthesia is hypotension with functional hypovolemia. Aggressive infusion therapy can reduce the hypotension effect. However, in conjunction with cardiopulmonary bypass, it can increase acute lung injury. We hypothesized that epidural anesthesia, by reducing cardiac sympathetic tonus, with subsequent better pulmonary flow, does not increase lung interstitial fluids. ⋯ Epidural anesthesia / analgesia does not increase interstitial lung fluids by increasing intrathoracic blood volume or the amount of infusion fluids in patients undergoing cardiac surgery under cardiopulmonary bypass. There is, also, a decreased duration of mechanical lung ventilation.
-
Clin. Exp. Pharmacol. Physiol. · Jul 2009
Comparative StudyReduced lung water transport rate associated with downregulation of aquaporin-1 and aquaporin-5 in aged mice.
1. The purpose of the present study was to examine lung water transport properties and the expression and regulation of the alveolar endothelial water channel aquaporin (AQP)-1 and the epithelial water channel AQP-5 in aged mouse lung using gene expression analysis and water permeability measurements. 2. In aged (20-24-month-old) mice, AQP-1 and AQP-5 mRNA expression decreased by 55.5 and 50.3%, respectively, compared with that in young (8-10-week-old) mice (P < 0.01). ⋯ The present study provides the first evidence of altered lung water transport associated with downregulation of AQPs in aged lung. Blood glucocorticoid hormone levels are important to maintain normal AQP-1 expression in the lung microvascular endothelium. Corticosteroid-induced AQP-1 upregulation may contribute to the role of corticosteroids in accelerating oedema clearance in aged lung.
-
Comparative Study
Ultrasound assessment for extravascular lung water in patients undergoing hemodialysis. Time course for resolution.
Sonographic B-lines, also known as lung comets, have been shown to correlate with the presence of extravascular lung water (EVLW). Absent in normal lungs, these sonographic findings become prominent as interstitia and alveoli fill with fluid. Characterization of the dynamics of B-lines, specifically their rate of disappearance as volume is removed, has not been previously described. In this study, we describe the dynamics of B-line resolution in patients undergoing hemodialysis. ⋯ B-line resolution appears to occur real-time as fluid is removed from the body, and this change was statistically significant. These data support thoracic ultrasound as a useful method for evaluating real-time changes in EVLW and in assessing a patient's physiologic response to the removal of fluid.
-
Am. J. Physiol. Lung Cell Mol. Physiol. · Jun 2009
Activated protein C protects against ventilator-induced pulmonary capillary leak.
The coagulation system is central to the pathophysiology of acute lung injury. We have previously demonstrated that the anticoagulant activated protein C (APC) prevents increased endothelial permeability in response to edemagenic agonists in endothelial cells and that this protection is dependent on the endothelial protein C receptor (EPCR). We currently investigate the effect of APC in a mouse model of ventilator-induced lung injury (VILI). ⋯ In addition, mice overexpressing EPCR on the pulmonary endothelium were protected from HV(T)-mediated injury. Finally, gene microarray analysis demonstrated that APC significantly altered the expression of genes relevant to vascular permeability at the ontology (e.g., blood vessel development) and specific gene (e.g., MAPK-associated kinase 2 and integrin-beta(6)) levels. These findings indicate that APC is barrier-protective in VILI and that EPCR is a critical participant in APC-mediated protection.