Articles: opioid-analgesics.
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Journal of periodontology · Feb 1996
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of 2 analgesic regimens for the control of postoperative periodontal discomfort.
A single blind study of 24 patients compared the postoperative periodontal pain relief and adverse effects associated with a pretreatment regimen with etodolac, a nonsteroidal anti-inflammatory drug (NSAID), to a typical pro re nada (prn) regimen with a combination of acetaminophen with hydrocodone. Patients selected required one or more periodontal osseous surgeries that were judged to involve relatively similar degrees of surgical manipulation. Patients in the etodolac group received two 300 mg capsules 30 minutes prior to surgery and then redosed themselves prn. ⋯ The side effects were minimal for both of the drugs studied. It was concluded that the analgesic regimens tested under clinical practice conditions were comparable in providing analgesia with minimum side effects in uncomplicated periodontal osseous surgery. Studies with larger numbers of patients are needed to definitively address whether these regimens are truly equivalent.
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Anaesth Intensive Care · Feb 1996
Randomized Controlled Trial Comparative Study Clinical TrialPatient-controlled epidural analgesia following caesarean delivery: a comparison of pethidine and fentanyl.
Pethidine and fentanyl have both been used to provide patient-controlled epidural analgesia (PCEA) following caesarean delivery. Both have been compared with epidural morphine but these drugs have not been compared with each other. Patient-controlled epidural analgesia was used in a prospective, randomized, double-blind, cross-over trial to compare fentanyl and pethidine for postoperative epidural analgesia in women having elective caesarean deliveries. ⋯ Results from 45 patients showed no difference in pain level outcomes, but pethidine scored better in all side-effects except for drowsiness at 48 hours. Patients were more satisfied with pethidine (P = 0.015) and overall 65% of patients preferred pethidine. We conclude that pethidine is a suitable drug for patient-controlled epidural analgesia and leads to greater patient satisfaction than does fentanyl.
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Zhonghua Hu Li Za Zhi · Feb 1996
Randomized Controlled Trial Comparative Study Clinical Trial[Continuous infusion of morphine in use of pain relief after upper abdominal surgery].
This study was designed as a prospective randomized comparative trial of continuous infusion of morphine (CIM) controlled by a micro-electric pump and traditional intermitted intramuscle injection of pethidine (IMP) to relieve pain after surgery. 40 patients submitted from upper abdominal surgery were divided into two groups, 20 patient receiving CIM and others using IMP. The amount of morphine used during the 24 hours was 0.5 mg/kg in CIM group. In IMP group, 20 patients were given standard intramuscular dosages of 1.5 mg/kg of pethidine, then, every 4-6 hours repeatedly within 24 hours after operation. ⋯ The result showed that all patients of CIM group had good analgesic effect (I and II degree), however, 10% of the patients in IMP group had only analgesic effect of I and II degree during the first 24 hours after operation. Their respiratory frequency, heart rate, BP and SpO2 had no significant difference in two groups. It woule appear that CIM is an efficacious and safe method for providing postoperative pain relief.
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomised trial of oral morphine for chronic non-cancer pain.
The use of opioid analgesics for chronic non-cancer pain is controversial. Some surveys report good pain relief and improvement in performance while others suggest a poor outcome with a propensity to psychological dependence or addiction. ⋯ In patients with treatment-resistant chronic regional pain of soft-tissue or musculoskeletal origin, nine weeks of oral morphine in doses up to 120 mg daily may confer analgesic benefit with a low risk of addiction but is unlikely to yield psychological or functional improvement.
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The Journal of urology · Jan 1996
Randomized Controlled Trial Comparative Study Clinical TrialPatient controlled analgesia for shock wave lithotripsy: the effect of self-administered alfentanil on pain intensity and drug requirement.
Second generation lithotriptors offer immersion-free treatment and a decrease in shock wave induced pain. Pain sensations caused by advanced lithotriptors vary widely and have a significant impact on clinical management. We tested patient controlled analgesia during extracorporeal shock wave lithotripsy (ESWL) and quantified analgesic requirements by means of patient controlled analgesia during ESWL of renal stones. ⋯ Patient controlled analgesia increases pain tolerance, decreases narcotic requirements, simplifies ESWL as an outpatient procedure and can be used to quantify analgesic requirements during lithotripsy. Pain and tolerance thresholds of electrocutaneous sensitivity are sensitive markers of pain tolerance during lithotripsy, which may be more pronounced in male patients.