Articles: sulfamethoxazole-drug-combination-trimethoprim.
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Sulfamethoxazole drug combination trimethoprim
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Am. J. Gastroenterol. · Dec 1989
Case ReportsFulminant liver failure and pancreatitis associated with the use of sulfamethoxazole-trimethoprim.
We report the case of a 26-yr-old patient with fulminant liver failure and acute hemorrhagic pancreatitis secondary to the use of trimethoprim-sulfamethoxazole (Bactrim DS). Our patient presented with skin rash and decreased C3 and C4 levels, which we believed was due to a hypersensitivity reaction secondary to the sulfonamide component (sulfamethoxazole). To our knowledge, this is the first case reported in which sulfamethoxazole-trimethoprim has been implicated as a cause of fulminant liver failure and acute hemorrhagic pancreatitis simultaneously, and emphasizes the need of discontinuing this medication as soon as there is evidence of liver and pancreatic dysfunction.