Articles: adult.
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Rev Bras Anestesiol · Jun 2006
[Effects of increasing spinal hyperbaric lidocaine concentrations on spinal cord and meninges: experimental study in dogs].
Lidocaine concentration potentially able to determine nervous tissue injury is still not well established. This study aimed at investigating the effect of increasing spinal lidocaine concentrations in single injection through Quincke needle. ⋯ In this study, spinal lidocaine in concentrations above 7.5% in single injection through Quincke needle has determined histological changes on spinal cord, but not on meninges.
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J Trauma Acute Care Surg · Oct 2015
Hyperoxic resuscitation improves survival but worsens neurologic outcome in a rat polytrauma model of traumatic brain injury plus hemorrhagic shock.
Many traumatic brain injury (TBI) patients experience additional injuries, including those that result in hemorrhagic shock (HS). Interactions between HS and TBI can include reduced brain O2 delivery, resulting in partial cerebral ischemia and worse neurologic outcome. This study tested the hypothesis that inspiration of 100% O2 during resuscitation following TBI and HS improves survival, reduces brain lesion volume, and improves neurologic outcome compared with resuscitation in the absence of supplemental O2. ⋯ The survival of rats following controlled cortical impact plus HS was greater following hyperoxic resuscitation. In contrast, neurologic outcomes were better following normoxic resuscitation.