Articles: adult.
-
Obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, provided significantly better renal responses than placebo in a phase 2 trial involving patients with lupus nephritis receiving standard therapy. ⋯ Among adults with active lupus nephritis, obinutuzumab plus standard therapy was more efficacious than standard therapy alone in providing a complete renal response. (Funded by F. Hoffmann-La Roche; REGENCY ClinicalTrials.gov number, NCT04221477.).
-
Observational Study
The Effect of Parental Weight and Genetics on the BMI of Very Low Birth Weight Infants as They Reach School Age.
Prematurely born individuals are usually of low or normal weight in childhood; in adulthood, however, their probability of being overweight is twice that of persons born at full term. There is not yet any way to predict the weight development of premature babies. ⋯ Extreme values of a polygenic BMI score are strongly associated with the weight development of preterm infants as they develop into children aged 10-14. The large effect size implies that this score may aid in the counseling of prematurely born children and their parents.
-
Pol. Arch. Med. Wewn. · Feb 2025
Efficacy of selected scales in the assessment of impaired awareness of hypoglycemia in adults with type 1 diabetes.
Impaired awareness of hypoglycemia (IAH) increases the risk of severe hypoglycemia. Questionnaires may allow for easy identification of patients with IAH and facilitate appropriate intervention. ⋯ The HypoA-Q, with a 9-point cut-off, demonstrated the highest sensitivity for diagnosing IAH, and may be considered the most valuable screening tool for IAH detection.