Articles: pandemics.
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Randomized Controlled Trial Multicenter Study
A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19.
Hydroxychloroquine probably provides no post-exposure benefit when taken within 4 days of COVID exposure.
pearl -
Complement Ther Clin Pract · May 2020
Randomized Controlled TrialEffects of progressive muscle relaxation on anxiety and sleep quality in patients with COVID-19.
Patients with Coronavirus Disease 2019(COVID-19) will experience high levels of anxiety and low sleep quality due to isolation treatment. Some sleep-improving drugs may inhibit the respiratory system and worsen the condition. Prolonged bedside instruction may increase the risk of medical infections. ⋯ Progressive muscle relaxation as an auxiliary method can reduce anxiety and improve sleep quality in patients with COVID-19.
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Randomized Controlled Trial Multicenter Study
Resuscitation of the patient with suspected/confirmed COVID-19 when wearing personal protective equipment: A randomized multicenter crossover simulation trial.
The aim of the study was to evaluate various methods of chest compressions in patients with suspected/confirmed SARS-CoV-2 infection conducted by medical students wearing full personal protective equipment (PPE) for aerosol generating procedures (AGP). ⋯ According to the results of this simulation trial, automated chest compression devices (ACCD) should be used for chest compression of patients with suspected/confirmed COVID-19. In the absence of ACCD, it seems reasonable to change the cardiopulmonary resuscitation algorithm (in the context of patients with suspected/confirmed COVID-19) by reducing the duration of the cardiopulmonary resuscitation cycle from the current 2-min to 1-min cycles due to a statistically significant reduction in the quality of chest compressions among rescuers wearing PPE AGP.
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Randomized Controlled Trial
Feasibility, Reliability, and Value of Remote Video-Based Trial Visits in Parkinson's Disease.
There is rising interest in remote clinical trial assessments, particularly in the setting of the COVID-19 pandemic. ⋯ Remote visits are feasible and reliable in a phase III clinical trial of individuals with early, untreated Parkinson's disease. These visits are shorter, reduce participant burden, and enable safe conduct of research visits, which is especially important in the COVID-19 pandemic.