Articles: vancomycin-administration-dosage.
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J. Thorac. Cardiovasc. Surg. · Jun 2014
Randomized Controlled Trial Comparative StudyWeight-based versus set dosing of vancomycin for coronary artery bypass grafting or aortic valve surgery.
This study was undertaken to identify a preferred dosing strategy for patients undergoing coronary artery bypass grafting or valve replacement procedures with cardiopulmonary bypass. ⋯ Weight-based vancomycin dosing before coronary artery bypass grafting or valve replacement results in vancomycin concentrations greater than 15 μg/mL consistently more than does standard 1-g dosing.
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Journal of critical care · Jun 2014
Observational StudyEvaluation of a dosing regimen for continuous vancomycin infusion in critically ill patients: An observational study in intensive care unit patients.
We aimed to evaluate a dosing algorithm for continuous vancomycin administration in intensive care unit patients. ⋯ The evaluated vancomycin dosing regimen for continuous infusion allowed rapid achievement of sufficient vancomycin serum levels. However, we frequently observed supra-therapeutic serum vancomycin concentrations in the first days of vancomycin treatment.
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Pediatr. Infect. Dis. J. · Jun 2014
ReviewNeonatal vancomycin continuous infusion: still a confusion?
Continuous infusions of vancomycin over 24 hours have been shown in adults to reduce drug toxicity, lower treatment costs and require fewer blood samples for therapeutic drug monitoring. They may also improve clinical outcome through earlier attainment of target drug concentrations. In neonates, there is no consensus on vancomycin dosing. We reviewed the literature to assess the evidence for vancomycin dosing regimens for continuous infusion in neonates. ⋯ Continuous infusions of vancomycin in neonates are well tolerated, require less blood sampling and may result in improved attainment of target concentrations. Further prospective studies are needed in this population.
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The objective of this study was to describe the pharmacokinetics of vancomycin in ICU patients and to examine whether contemporary antibiotic dosing results in concentrations that have been associated with favourable response. ⋯ This study demonstrated large interindividual variability in vancomycin pharmacokinetic and pharmacodynamic target attainment in ICU patients. These data suggests that a re-evaluation of current vancomycin dosing recommendations in critically ill patients is needed to more rapidly and consistently achieve sufficient vancomycin exposure.