Articles: surgery.
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Clin. Pharmacol. Ther. · Dec 1987
Randomized Controlled Trial Clinical TrialThe additive analgesic efficacy of acetaminophen, 1000 mg, and codeine, 60 mg, in dental pain.
In a double-blind, randomized, single-dose trial the analgesic contribution of acetaminophen, 1000 mg, and codeine, 60 mg, was determined. The study was a 2 X 2 factorial experiment in which 120 patients suffering from pain as a result of oral surgery rated their pain intensity and pain relief for up to 5 hours after a single dose of one of: 1000 mg acetaminophen, 60 mg codeine, 1000 mg acetaminophen plus 60 mg codeine, or placebo. The factorial analysis showed that both 1000 mg acetaminophen and 60 mg codeine made a statistically significant (P less than 0.05) contribution to the analgesic effectiveness of the combination on all measures of efficacy (sum of pain intensity differences, largest pain intensity difference, total pain relief, largest pain relief, and time to remedication). The incidence of adverse effects did not appear to differ among the treatments, including placebo.
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The best quality long-lasting results require attention to the diagnosis of the precise anatomic problems followed by the architectural planning--the art of making beautiful highlights, shadows, and curves where indicated to produce a result that is aesthetically pleasing. Attention to the details of the surgical planning, execution of surgery, and postoperative care are essential to minimize untoward results and problems and produce a happy patient and pleased surgeon.
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A 2-day study to assess the safety and efficacy of a combination analgesic, Stopayne (Rio Ethicals), was conducted in 23 postoperative plastic surgery patients with pain of moderate to severe intensity. Statistically significant pain relief was attained, with 2 (9%) patients reporting complete relief 1 hour after taking the tablets and 19 (82%) reporting satisfactory relief (P less than 0.01). ⋯ The average time taken for analgesia to occur was 37.7 min and it lasted an average of 3.8 h. On being woken by pain 18 (78%) patients reported that they were able to sleep again after taking the study drug; 19 patients reported that the tablets helped them to fall asleep.