Articles: interstitial-lung-diseases.
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Ned Tijdschr Geneeskd · Dec 1998
Review[Bronchoalveolar lavage in the diagnosis of diffuse interstitial lung disease].
Since the introduction of bronchoalveolar lavage (BAL), this technique is used both clinically and for research. Use of BAL as a diagnostic aid was introduced fairly recently. For the different steps of the procedure a standardized approach has been proposed. ⋯ Smoking and pharmacotherapy affect the results of the analysis. BAL is a safe procedure with hardly any side effects. This method may in some diseases replace more invasive diagnostic procedures such as biopsy by demonstrating characteristic cells or micro-organisms.
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AJR Am J Roentgenol · Dec 1998
Nonspecific interstitial pneumonia with fibrosis: high-resolution CT and pathologic findings.
The purpose of our study was to describe high-resolution CT findings of nonspecific interstitial pneumonia with fibrosis and to compare findings seen on CT with pathologic findings. ⋯ On high-resolution CT, nonspecific interstitial pneumonia with fibrosis is most commonly revealed as patchy subpleural areas of ground-glass opacity mixed with irregular linear opacity or bronchial dilatation. These areas represent interstitial thickening caused by varying degrees of interstitial inflammation, fibrosis, or both.
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Comparative Study
Idiopathic nonspecific interstitial pneumonia/fibrosis: comparison with idiopathic pulmonary fibrosis and BOOP.
Based on past difficulties in clinically differentiating patients with idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans-organizing pneumonia (BOOP), and nonspecific interstitial pneumonia/fibrosis (NSIP), which all manifest clinically as interstitial lung disease, experience with pathologically confirmed examples of the three diseases was reviewed to compare clinical profiles and prognosis and to define NSIP more clearly. Thirty-one patients (15 males and 16 females) were pathologically identified as NSIP and subclassified into either the cellular (n=16) or fibrotic group (n=15). All 31 patients were clinically considered to be idiopathic NSIP cases. ⋯ Two subgroups of NSIP can be recognized histologically: patients in the fibrotic group had a less favourable outcome than those in the cellular group. BOOP and NSIP had a more favourable outcome than IPF. In conclusion, idiopathic nonspecific interstitial pneumonia can be differentiated from other types of idiopathic interstitial pneumonia, both pathologically and clinically.