Articles: low-back-pain.
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Transient receptor potential ankyrin 1 (TRPA1) is implicated in physiological and pathological nociceptive signaling, but the clinical benefit of TRPA1 antagonists in chronic pain is not clearly demonstrated. LY3526318 is an oral, potent, and selective novel TRPA1 antagonist. The Chronic Pain Master Protocol was used to evaluate the safety and efficacy of LY3526318 in 3 randomized, placebo-controlled, proof-of-concept studies in knee osteoarthritis pain (OA), chronic low back pain (CLBP), and diabetic peripheral neuropathic pain (DPNP). ⋯ LY3526318 showed a potential drug-induced hepatotoxic effect posing a risk for clinical development. No other safety signals were identified. LY3526318 showed potential for different responses among chronic pain indications and patient subpopulations, highlighting challenges in developing TRPA1 antagonists but supporting their value as a target in managing chronic pain.
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Comparative Study
Comparative Analysis of Lower Back Pain and Phantom Pain in Unilateral Lower Limb Amputees: A Study on Amputee Football Players vs. Non-Athletes.
Background and Objectives: Amputation poses a significant clinical and therapeutic challenge, with over 90.0% of amputations involving the lower limbs, of which 75.0% are associated with diabetes and peripheral artery disease. Individuals with lower limb amputations often experience secondary disabilities. This study aimed to compare the frequency and intensity of lower back pain and phantom pain in individuals with unilateral lower limb amputations who were amputee football players with those who did not participate in adaptive sports. ⋯ The players exhibited significantly better motor function and lower levels of disability. Preoperative limb pain was a significant risk factor for phantom pain in the study group. Adaptive sports can not only support the development of motor and social skills but also contribute to reducing the severity of lower back pain, which leads to a decrease in the level of disability.
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Little research has assessed the efficacy of interdisciplinary pain management programs (IPMPs) for complex regional pain syndrome (CRPS), whereas evidence shows that IPMPs are effective for low back pain (LBP) and chronic widespread pain (CWP). This study aimed to determine whether outcomes following an IPMP differ for people with CRPS compared to LBP and CWP. In addition, we determined whether it is possible to predict IPMP outcomes using baseline characteristics. ⋯ People with CRPS, LBP, and CWP experience similar benefits following an IPMP. This supports the use of IPMPs for people with CRPS.
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Nonspecific chronic low back pain (NCLBP) is one of the most common manifestations of degenerative spondylitis. It affects many patients of all ages and seriously interferes with quality of life. However, the associations between NCLBP, sagittal alignment and age remain unclear. We aimed to investigate the typical features of sagittal alignment in individuals with NCLBP and to discuss the relationships between age and these NCLBP-related changes in sagittal alignment. ⋯ Although decreased lumbar lordosis is the most typical sagittal feature in patients with NCLBP, there are still differences in sagittal alignment between different ages. Compared with young patients, elderly patients with NCLBP more commonly present with a decompensated pattern of the anterior inclination of the trunk as the main sagittal alignment abnormality. TPA is more predictive than LL for the diagnosis of geriatric NCLBP.
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The aim of this study was to evaluate the performance and safety of a new hernia blocking system (HBS), implanted after a limited discectomy, to prevent recurrence of lumbar disc herniation. ⋯ The implantation of an HBS is a feasible and safe procedure that prevents early disc herniation recurrence in patients at high risk of reherniation.