Articles: general-anesthesia.
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Letter Randomized Controlled Trial Comparative Study
Comparison of size 3 and size 4 i-gel® in 50-60 kg female patients: A prospective randomized crossover trial.
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Eur J Orthop Surg Tr · Dec 2019
Randomized Controlled Trial Comparative StudyA comparison of continuous interscalene block versus general anesthesia alone on the functional outcomes of the patients undergoing arthroscopic rotator cuff repair.
The aim of this prospective and randomized study was to compare the effects of general anesthesia to the combination of general anesthesia and continuous interscalene block on postoperative pain and functional outcomes in patients undergoing arthroscopic rotator cuff repair. ⋯ Level II, Randomized Controlled Trial, Treatment Study.
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Anesthesia and analgesia · Dec 2019
Randomized Controlled Trial Multicenter StudyDexmedetomidine for Improved Quality of Emergence From General Anesthesia: A Dose-Finding Study.
Dexmedetomidine provides smooth and hemodynamically stable emergence at the expense of hypotension, delayed recovery, and sedation. We investigated the optimal dose of dexmedetomidine for prevention of cough, agitation, hypertension, tachycardia, and shivering, with minimal side effects. ⋯ D 1 at the end of surgery provides the best quality of emergence from general anesthesia including the control of cough, agitation, hypertension, tachycardia, and shivering. D 0.5 also controls emergence phenomena but is less effective in controlling cough. The 3 doses do not delay extubation. However, they cause dose-dependent hypotension.
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Randomized Controlled Trial
Effects of serum from breast cancer surgery patients receiving perioperative dexmedetomidine on breast cancer cell malignancy: A prospective randomized controlled trial.
Adrenergic receptors (ARs) have gained attention for their involvement in breast cancer (BC) progression. Dexmedetomidine, a selective α2 -AR agonist, has been reported to increase the malignancy of BC cells in vitro or stimulate tumor growth in mice. However, clinical evidence is lacking. ⋯ The mean percentage change from post to preoperative values in these cell functions was significantly larger in the dexmedetomidine group than in the control group (proliferation, 30.44% vs 8.45%, P = .0024; migration, 15.90% vs 3.25%, P = .0015; invasion, 8.17% vs 2.13%, P = .04). In conclusion, these findings suggest that in patients undergoing surgery for primary BC, perioperative administration of dexmedetomidine might influence the serum milieu in a way that favors the malignancy of MCF-7 cells. Clinical trial registration: NCT03108937.
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African health sciences · Dec 2019
Randomized Controlled TrialEffect of removal of AuraOnce™ laryngeal mask in awake or deep anaesthesia: a randomized controlled trial.
The manufacturer Ambu® recommends that the AuraOnce™ laryngeal mask be removed once the patient is fully awake. Studies have shown benefit in removal of the laryngeal mask airway while a patient is deeply anaesthetized. Current evidence is inconclusive, as to which approach is preferable and safer in adults. ⋯ The removal of the AuraOnce™ laryngeal mask while the patient is still deeply anaesthetised is not as safe as or safer than awake removal.