Articles: neuralgia.
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Meta Analysis Comparative Study
Treatments for postherpetic neuralgia--a systematic review of randomized controlled trials.
A number of different therapies have been used for postherpetic neuralgia. We decided to conduct a systematic review of existing randomized controlled trials. ⋯ Based on evidence from randomized trials, tricyclic anti-depressants appear to be the only agents of proven benefit for established postherpetic neuralgia.
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EMLA cream is an acronym for eutectic mixture of local anesthetics. It contains lidocaine and prilocaine creams. A eutectic preparation, applied topically, penetrates into the dermis after an application period of 1 to 2 hours. This case report describes the successful treatment with EMLA cream of post-herpetic neuralgia, which was resistant to other modes of therapy, and briefly discusses the pharmacology of EMLA cream.
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Acta Otolaryngol Suppl · Jan 1996
Case ReportsTwo cases with glossopharyngeal neuralgia treated by nerve reaction: oropharyngeal approach.
Two patients with idiopathic glossopharyngeal neuralgia received glossopharyngeal nerve resection by the oropharyngeal method, and their symptoms were relieved. Both patients had suffered proxysms of severe pain in the unilateral glossopharyngeal innervation for many years, and pharmaceutical treatment had been made in vain and, although surgical intervention in one patient had resulted in temporary relief, it had not been possible to prevent recurrence. As the identification of trigger zones by the method of local nerve block caused us to think that surgical treatment would be more effective in both patients, the glossopharyngeal nerve was resected, using the oropharyngeal method, with a view to attaining permanent symptomatic relief. Consequently, satisfactory results were obtained.
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Neurobiology of disease · Jan 1996
Cutaneous innervation density in the allodynic form of postherpetic neuralgia.
The relationship between deafferentation, sensory function, and pain was explored in 18 subjects with chronic postherpetic neuralgia (PHN). Subjective thresholds for warmth, cooling, and heat pain were measured quantitatively in painful skin areas and compared with normal contralateral skin. The severity of allodynia was graded in the affected area. ⋯ Immunofluorescence with the axonal marker PGP 9.5 revealed a reduction in density of innervation of the epidermis, the dermal-epidermal junction, and the eccrine sweat glands in PHN skin. In painful PHN skin, the reduction in innervation density was positively correlated with the magnitude of the thermal sensory deficits. However, loss of cutaneous innervation was inversely correlated with allodynia, indicating that surviving cutaneous primary afferent nociceptors that are spontaneously active and/or sensitized contribute to PHN pain and allodynia.
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Acta Derm. Venereol. · Jan 1996
Case ReportsPruritus circumscriptus sine materia: a sequel of postzosteric neuralgia. Evaluation by quantitative psychophysical examination and laser-evoked potentials.
A case of circumscribed pruritus existing since 1 year on clinically uninvolved skin is reported, in which careful history revealed a 5-year previous episode of herpes zoster in the same dermatome. Impairment of cutaneous sensitivity was evaluated by use of a quantitative psychophysical examination and laser-evoked cortical potentials (LEP).