Articles: veins.
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Whole-body venous capacity was examined in conscious 4-month-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto normotensive (WKY) rats by determining mean circulatory filling pressure (MCFP) and blood volume. The MCFP was determined in conscious animals after briefly arresting the circulation by inflating an indwelling balloon in the right atrium. Blood volume was determined by dilution of 125I-albumin and 51Cr-red cells. ⋯ The linear regression line for delta interstitial fluid pressure and delta fluid volume was estimated for each rat and the inverse of this slope represented ETTC, which averaged 7.4 +/- 1.0 and 9.6 +/- 2.1 ml/kg/mm Hg (p greater than 0.3) in SHR and WKY respectively. Thus, there were no significant differences in interstitial fluid pressure or ETTC between female SHR and WKY. The results of this study confirm a decreased venous capacity in male SHR with established hypertension and provide new information indicating no measurable abnormalities in interstitial fluid pressure or effective total tissue compliance in adult female SHR as compared with WKY.
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Limb loss is the outcome in one third of previously reported popliteal artery injuries. This report summarizes 83 injuries with an amputation rate of 9.6%. Penetrating traumas accounted for 61 (73%) injuries and blunt traumas for 22 (27%). ⋯ Routine distal catheter thrombectomy and frequent intraoperative arteriography promote and confirm complete reconstruction. Early performance of four quadrant fasciotomy is indicated if compartmental hypertension is suspected. Thorough debridement of injured and questionably viable soft tissue and adequate fracture stabilization are integral parts of successful revascularization.
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One hundred consecutive patients with femoropopliteal autogenous vein grafts for limb salvage were reviewed five years later. In this group 40% died and 30% of the limbs had been lost at the end of five years. ⋯ Temporary graft patency was effective in preserving ischemic tissue by facilitating healing of ulcers or limited amputations. Femoral-popliteal bypass grafting in the presence of advanced ischemia is capable of improving the quality of life for many of these patients.