Articles: hyperalgesia.
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Arch Phys Med Rehabil · Dec 2012
Central hypersensitivity in patients with subacromial impingement syndrome.
To investigate the presence of primary and secondary hyperalgesia among subjects with chronic subacromial impingement syndrome (SIS) compared with pain-free controls. ⋯ This study provides further evidence that patients with SIS have significantly lower PPTs than do controls in both local and distal areas from their affected arm consistent with primary and secondary hyperalgesia, respectively. Data suggest the presence of central sensitization among subjects with chronic SIS.
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Zhong Xi Yi Jie He Xue Bao · Dec 2012
Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain.
To study the analgesic effects of naringenin on chronic constriction injury (CCI) model of neuropathic pain. ⋯ The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.
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Ever since the characterization of schizophrenia, clinicians have noted abnormal pain sensitivity in their patients. The published literature, however, is inconsistent concerning the nature of the change reported. The objective of this study was to characterize the pain response profile of schizophrenic patients by providing both acute and prolonged (i.e., rapidly repeating) painful stimuli to schizophrenic participants and control subjects. ⋯ Results indicate that schizophrenic subjects present a specific experimental pain response profile, characterized by elevated sensitivity to acute pain but reduced sensitivity to prolonged pain.
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Zhong Xi Yi Jie He Xue Bao · Dec 2012
Effects of electroacupuncture on expression of c-fos protein in the spinal dorsal horn of rats with chronic visceral hyperalgesia.
Acupuncture is widely used in clinics to suppress chronic visceral pain in patients with irritable bowel syndrome (IBS); however, the exact neurobiological mechanisms for its therapeutic effects need further exploration. The aim of this study was to investigate the possible involvement of spinal neurons in the effects of electroacupuncture (EA) in relieving chronic visceral hyperalgesia in a rat model of IBS. ⋯ The abnormally high neuronal excitability in the spinal dorsal horn may be an important reason underlying the visceral hyperalgesia in IBS model rats. EA treatment can relieve the chronic visceral hyperalgesia in IBS rats by suppressing the abnormal neuronal excitability in the spinal dorsal horn.
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We have to trust the patient. Pain is undertreated. Inadequate treatment has adverse consequences. ⋯ They are responsive to opioid analgesia. They need baseline opioids ("opioid debt"), mostly a well-stabilized OST. They require higher doses, more frequent dosing and longer opioid administration.