Articles: adolescent.
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Pharmacol. Biochem. Behav. · Feb 2007
ReviewHPA function in adolescence: role of sex hormones in its regulation and the enduring consequences of exposure to stressors.
The hypothalamic-pituitary-adrenal (HPA) axis is one of the physiological systems involved in coping with stressors. There are functional shifts in the HPA axis and its regulation by sex hormones over the lifespan that allow the animal to meet the challenges of the internal and external environment that are specific to each stage of development. Sex differences in HPA function emerge over adolescence, a phenomenon reflecting the concomitant initiation of regulatory effects of sex hormones. ⋯ Although research has been scarce, there is a growing evidence that exposure to stressors in adolescence may alter behavioural responses to drugs and cognitive performance in adulthood. However, the effects reported appear to be stressor-specific and sex-specific. Such research may contribute toward understanding the increased risk for drug abuse and psychopathology that occurs over adolescence in people.
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The aims of this article are to summarize the reports from various organizations and existing research applicable to the concept of adolescent consent, and to assemble guidelines to aid in consent decisions for research that focuses on adolescents. The regulations from the United States Department of Health and Human Service and the National Commission for Protection of Human Subjects are reviewed, along with legal, ethical, and research-based issues associated with obtaining consent from adolescents. A set of guidelines has been compiled to provide direction for the appropriate consent process with this special population.
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This paper begins with a review of the problem of teen pregnancy in the United States. Domestic trends are compared with those of other developed countries. Antecedents of the problem are discussed. ⋯ An analysis of the different ways in which the problem can be framed and the implications for solutions of the problem follow. Examples of promising teen pregnancy and STD/HIV/AIDS prevention programs are provided. The paper ends with a recommendation for an eclectic approach to framing the problem and possible solutions.
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Review Case Reports
Abdominal wall pain caused by cutaneous nerve entrapment in an adolescent girl taking oral contraceptive pills.
The etiology of chronic abdominal pain can be elusive. The diagnostic workup, therefore, often includes superfluous and expensive tests, as well as invasive procedures which do not contribute to the final diagnosis. Studies have shown that some patients suffer from prolonged pain in the abdominal wall and often are misdiagnosed and treated as having a visceral source for their complaints. ⋯ After the involved cutaneous nerve was selectively blocked by subcutaneous infiltration, the pain disappeared immediately and completely. Recognition of this apparently unusual condition can lead to gratifying results. It is proposed that oral contraceptive therapy may have caused changes in the abdominal wall which led to nerve entrapment and the ensuing severe, prolonged pain.