Articles: acute-pain.
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Randomized Controlled Trial
The role of intercostal nerve preservation in acute pain control after thoracotomy.
To evaluate whether the acute pain experienced during in-hospital recovery from thoracotomy can be effectively reduced by the use of intraoperative measures (dissection of the neurovascular bundle prior to the positioning of the Finochietto retractor and preservation of the intercostal nerve during closure). ⋯ In patients undergoing thoracotomy, protecting the neurovascular bundle prior to positioning the retractor and preserving the intercostal nerve during closure can minimize pain during in-hospital recovery.
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Randomized Controlled Trial
Onset of action of a lozenge containing flurbiprofen 8.75 mg: a randomized, double-blind, placebo-controlled trial with a new method for measuring onset of analgesic activity.
A new onset-of-action model was utilized to distinguish the pharmacologic activity of flurbiprofen 8.75mg delivered in a lozenge from the demulcent effect of the lozenge base. In a randomized, double-blind, placebo-controlled trial, patients with sore throat rated pain on a Sore Throat Pain Intensity Scale before taking one flurbiprofen or placebo lozenge and at frequent (2-minute) intervals over the first hour after treatment. Further ratings of the Sore Throat Pain Intensity Scale and other patient-reported outcomes (difficulty swallowing, swollen throat, pain relief) were obtained at varying intervals over 6 hours. ⋯ Efficacy of flurbiprofen lozenge was demonstrated for 3.5-4hours on the 4 patient-reported outcomes (all P<0.05 compared with placebo). There were no serious adverse events. This patient-centered onset-of-action model identifies the initiation of pain relief in patients who are definite drug responders, here demonstrating that a flurbiprofen 8.75-mg lozenge provides early relief of sore throat.
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J Back Musculoskelet Rehabil · Jan 2014
Randomized Controlled TrialEffects of different frequencies of conventional transcutaneous electrical nerve stimulation on pressure pain threshold and tolerance.
Pulse frequency is one of the key determinants of analgesic outcomes by transcutaneous electrical nerve stimulation (TENS). However, optimal settings remain unclear. ⋯ These findings established that, at 150 pps conventional TENS, threshold and tolerance values were consistently higher. These results are presented to inform future research regarding optimal conventional TENS parameters and to provide support for clinical applications.
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Randomized Controlled Trial Comparative Study
Intra-articular Morphine versus Lidocaine for Acute Knee Pain.
The authors conducted an unfunded randomized controlled trial approved by the Brooke Army Medical Center (BAMC) Institutional Review Board (IRB) to determine the possible efficacy of intra-articular morphine for pain in acute knee injuries. ⋯ Further investigation with a larger sample is required to explore whether these results are statistically significant and the possible superiority of intra-articular morphine to lidocaine for acute knee pain.
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Technol Health Care · Jan 2014
Randomized Controlled TrialEvaluation of a ubiquitous and interoperable computerised system for remote monitoring of ambulatory post-operative pain: a randomised controlled trial.
For economic reasons, i.e., to reduce costs of in-hospital patient accommodations, constant pressure has been applied in recent years to increase the percentage of ambulatory surgeries. Effective control of post-operative pain after ambulatory surgery is challenging to all health professionals. Computerised systems are being implemented more frequently for remote patient monitoring, including during the at-home post-operative period. ⋯ The findings demonstrated the feasibility and suitability of the proposed system for pain management. Its handling was user-friendly, without requiring advanced skill or prior experience. In addition, the results showed that the guidance of health care professionals is essential to patients' satisfaction and positive experience with the system. There were no significant group differences with respect to improvements in the quality of pain treatment; however, this can be explained by the low pain scores registered in both groups, related to the type of surgical interventions recruited and the degrees of pain that are easily treated. To evaluate the benefits from a patient-centred perspective, studies of major ambulatory surgeries or of patients in chronic pain, including oncologic and non-oncologic pain resistant to treatment, are necessary.