Articles: intensive-care-units.
-
Critical care medicine · Feb 1995
Randomized Controlled Trial Comparative Study Clinical TrialComparison of propofol and midazolam for sedation in intensive care unit patients.
To evaluate the comparative safety and effectiveness of intravenous infusion of propofol or midazolam when used for 12 to 24 hrs of sedation and to evaluate the quality of sedation during stimulation. ⋯ Propofol was as safe and as efficacious as midazolam for continuous intravenous sedation. The quality of sedation was better in the propofol group.
-
Randomized Controlled Trial Clinical Trial
Individualized developmental care for the very low-birth-weight preterm infant. Medical and neurofunctional effects.
To investigate the effectiveness of individualized developmental care in reducing medical and neurodevelopmental sequelae for very low-birth-weight infants. ⋯ Very low-birth-weight preterm infants may benefit from individualized developmental care in the neonatal intensive care unit in terms of medical and neurodevelopmental outcome.
-
Randomized Controlled Trial Clinical Trial
Critical care unit noise and rapid eye movement (REM) sleep.
To determine if Critical Care Unit (CCU) sound levels suppress rapid eye movement (REM) sleep. ⋯ Although generalization of the results to CCU patients is limited (because of the use of laboratory subjects), the results provided convincing support for a causal relationship between CCU sound levels and suppression of REM sleep.
-
J. Cardiothorac. Vasc. Anesth. · Apr 1993
Randomized Controlled Trial Comparative Study Clinical TrialInfusion of propofol versus midazolam for sedation in the intensive care unit following coronary artery surgery.
The use and the hemodynamic effects of propofol and midazolam were studied during titrated continuous infusions to deep sedation (sedation level 5: asleep, sluggish response to light glabellar tap or loud auditory stimulus) following coronary artery surgery. The drugs were compared in 30 ventilated patients in an open randomized study. The duration of infusion was approximately 570 minutes in both groups. ⋯ The time from stopping sedation to patient responsiveness was 11 +/- 8 minutes in the propofol group and 72 +/- 70 minutes in the midazolam group (P < 0.001), and the time from stopping sedation to extubation was 250 +/- 135 minutes and 391 +/- 128 minutes (P < 0.014), respectively. Following the loading dose of propofol, there was a fall in blood pressure (BP) (mean from 80 +/- 11 mmHg to 67.5 +/- 10 mmHg; P < 0.05). After approximately 15 minutes, BP started to rise but remained below pretreatment level throughout sedation.(ABSTRACT TRUNCATED AT 250 WORDS)
-
Randomized Controlled Trial Clinical Trial
Effects of personal control over hospital noise on sleep.
Critical Care Unit (CCU) sound levels, subjective stress due to noise, and sleep were studied in 105 female volunteers in a simulated hospital environment. Subjects were randomly assigned to instruction in personal control over noise via the availability of a sound conditioner, no instruction in personal control over noise, or quiet conditions. Subjects in the two noise conditions heard audiotape-recorded CCU nighttime sounds while attempting to sleep overnight in the laboratory. ⋯ As predicted, scores for subjective stress due to CCU sounds yielded significant relationships with 9 of 16 measures of sleep (all ps less than .01). Hierarchical multiple regressions showed that 13% (p less than .001) and close to 6% (p less than .05) of the variance in sleep efficiency was accounted for by CCU sound levels and noise-induced subjective stress, respectively. Thirty-eight percent (p less than .001) of the variance in Rapid Eye Movement sleep was accounted for by CCU sound levels.