Articles: coronavirus.
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After its outbreak in China, the novel COronaVIrus Disease 19 is spreading across the globe. It is an emergency the world has never seen before. ⋯ When dealing with COronaVIrus Disease 19, policy makers and healthcare personnel should consider the indirect effects on the treatment of non-communicable diseases.
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J. Med. Internet Res. · Aug 2020
ReviewHazards of the Cytokine Storm and Cytokine-Targeted Therapy in Patients With COVID-19: Review.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged medicine and health care on a global scale. Its impact and frightening mortality rate are in large part attributable to the fact that there is a lack of available treatments. It has been shown that in patients who are severely ill, SARS-CoV-2 can lead to an inflammatory response known as cytokine storm, which involves activation and release of inflammatory cytokines in a positive feedback loop of pathogen-triggered inflammation. Currently, cytokine storm is one of the leading causes of morbidity and mortality in SARS-CoV-2, but there is no proven treatment to combat this systemic response. ⋯ The severity of the cytokine storm, measured by elevated levels of interleukin-1B, interferon-γ, interferon-inducible protein 10, and monocyte chemoattractant protein 1, was associated with COVID-19 disease severity. Many treatment options with different targets have been proposed during the early stages of the COVID-19 pandemic, ranging from targeting the virus itself to managing the systemic inflammation caused by the virus and the excessive cytokine response. Among the different agents to manage cytokine storm in patients with COVID-19, there is developing support for convalescent plasma therapy particularly for patients who are critically ill or mechanically ventilated and resistant to antivirals and supportive care. Treatment options that were proposed in the beginning phases of the pandemic were multidimensional, and further research is needed to develop a more established treatment guideline.
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Disaster Med Public Health Prep · Aug 2020
Holistic Analysis of Coronavirus Literature: A Scientometric Study of the Global Publications Relevant to SARS-CoV-2 (COVID-19), MERS-CoV (MERS) and SARS-CoV (SARS).
In late December 2019, a cluster of patients with pneumonia caused by an unknown pathogen was reported from Wuhan, Hubei Province, China. The pathogen has been identified as a novel coronavirus, severe acute respiratory syndrome 2 (SARS-CoV-2) and the disease has been named as coronavirus disease 2019 (COVID-19). The objective of this study was to perform the first holistic scientometric evaluation of coronavirus publications. ⋯ While in the 1980s, the United States and developed countries from Europe were major source countries and the virus was identified only as an animal disease in the literature and its biological and genetic structure was investigated, in the 2000s, China became a major contributor of coronavirus literature because the SARS outbreak originated from southern China. Almost all most-cited publications in this period are related to SARS and the ACE2 protein.