Articles: coronavirus.
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Zhonghua Shao Shang Za Zhi · Jul 2020
[Management strategy of burn and wound care ward during coronavirus disease 2019 pandemic].
The prevention and control of coronavirus disease 2019 (COVID-19) has already entered a key period. The patients treated in the burn and wound care ward are susceptible to viral infection because of disease, age and other factors, so it is very important to manage the burn and wound care ward during the prevention and control of COVID-19 pandemic. In this paper, combining with the key clinical problems of prevention and control in hospital during the epidemic period of COVID-19 infection, medical evidence, and clinical and management experience, the authors formulate prevention and control management strategy of the author's unit in order to provide reference for prevention and control of burn and wound care ward.
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The outbreak of coronavirus disease 2019 (COVID-19) has caused a public catastrophe and global concern. The main symptoms of COVID-19 are fever, cough, myalgia, fatigue and lower respiratory tract infection signs. Almost all populations are susceptible to the virus, and the basic reproduction number (R0) is 2.8-3.9. The fight against COVID-19 should have two aspects: one is the treatment of infected patients, and the other is the mobilization of the society to avoid the spread of the virus. The treatment of patients includes supportive treatment, antiviral treatment, and oxygen therapy. For patients with severe acute respiratory distress syndrome (ARDS), extracorporeal membrane oxygenation (ECMO) and circulatory support are recommended. Plasma therapy and traditional Chinese medicine have also achieved good outcomes. This review is intended to summarize the research on this new coronavirus, to analyze the similarities and differences between COVID-19 and previous outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) and to provide guidance regarding new methods of prevention, diagnosis and clinical treatment based on autodock simulations. ⋯ In evolutionary history, these three coronaviruses have some similar biological features as well as some different mutational characteristics. Their receptors and routes of transmission are not all the same, which makes them different in clinical features and treatments. We discovered through the autodock simulations that Met124 plays a key role in the efficiency of drugs targeting ACE2, such as remdesivir, chloroquine, ciclesonide and niclosamide, and may be a potential target in COVID-19.
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In late 2019, an outbreak of a severe respiratory disease caused by an emerging coronavirus, SARS-CoV-2, resulted in high morbidity and mortality in infected humans. Complete understanding of COVID-19, the multi-faceted disease caused by SARS-CoV-2, requires suitable small animal models, as does the development and evaluation of vaccines and antivirals. Since age-dependent differences of COVID-19 were identified in humans, we compared the course of SARS-CoV-2 infection in young and aged Syrian hamsters. ⋯ The latter developed conspicuous alveolar and perivascular edema, indicating vascular leakage. In contrast, we observed rapid lung recovery at day 14 after infection only in young hamsters. We propose that comparative assessment in young versus aged hamsters of SARS-CoV-2 vaccines and treatments may yield valuable information, as this small-animal model appears to mirror age-dependent differences in human patients.
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Zhonghua Shao Shang Za Zhi · Jul 2020
[Experience in the treatment of burn patients combined with inhalation injury during the epidemic of coronavirus disease 2019].
Objective: To introduce the experience in treating burn patients with inhalation injury during the epidemic of coronavirus disease 2019 (COVID-19). Methods: Six burn patients combined with inhalation injury were hospitalized in Department of Burns of Tongren Hospital of Wuhan University & Wuhan Third Hospital from February 1 to March 1 in 2020 during the high-incidence period of COVID-19, including 4 males and 2 females, aged 21-63 years, admitted at 2-4 hours after burns, with total burn areas of 1%-20% total body surface area (TBSA) and full-thickness burn areas of 1%-12% TBSA. Among them, 1 case had severe inhalation injury, 2 cases had mild inhalation injury, and 3 cases had moderate inhalation injury. ⋯ After treatment for 14-32 days, 6 patients were cured and discharged. Conclusions: During COVID-19 pandemic, burn patients combined with inhalation injury should be treated under condition of good protection for doctors and nurses. Meanwhile, virus should be actively screened to reduce the risk of COVID-19 infection among doctors and patients.
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Psychology & marketing · Jul 2020
Benefits of heroes to coping with mortality threats by providing perceptions of personal power and reducing unhealthy compensatory consumption.
Mortality threats are among the strongest psychological threats that an individual can encounter. Previous research shows that mortality threats lead people to engage in unhealthy compensatory consumption (i.e., overeating), as a maladaptive coping response to threat. ⋯ We test and find support for our predictions in a series of four studies that include real-world Twitter data after a series of terrorist attacks in 2016-2017, and three experimental studies conducted online and in the field with behavioral measures after Day of the Dead and during COVID-19 pandemic. These findings advance the literature on compensatory consumption, mortality threats, and the psychological functions of heroes.