Articles: sepsis.
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Minerva anestesiologica · Dec 2013
Multicenter StudyClinical characteristics and prognosis of pneumonia and sepsis: multicenter study.
Pneumonia is the primary source of sepsis and is significantly associated with mortality. However, only a few studies focus on its clinical characteristics and outcomes. ⋯ In patients admitted with sepsis, the pneumonia infection independently predicts 28-day in-hospital mortality. Combining the levels of serum lactate and PF ratio could be a useful approach in predicting mortality of these patients.
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Randomized Controlled Trial Multicenter Study
Probiotic effects on late-onset sepsis in very preterm infants: a randomized controlled trial.
Late-onset sepsis frequently complicates prematurity, contributing to morbidity and mortality. Probiotics may reduce mortality and necrotizing enterocolitis (NEC) in preterm infants, with unclear effect on late-onset sepsis. This study aimed to determine the effect of administering a specific combination of probiotics to very preterm infants on culture-proven late-onset sepsis. ⋯ The probiotics B infantis, S thermophilus, and B lactis significantly reduced NEC of Bell stage 2 or more in very preterm infants, but not definite late-onset sepsis or mortality. Treatment with this combination of probiotics appears to be safe.
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Intensive care medicine · Dec 2013
Randomized Controlled Trial Multicenter StudyBleeding and risk of death with hydroxyethyl starch in severe sepsis: post hoc analyses of a randomized clinical trial.
We aimed to characterize the degree and clinical importance of bleeding in patients treated with hydroxyethyl starch (HES). ⋯ In post hoc analyses of patient with severe sepsis, treatment with HES increased the risk of bleeding which was associated with increased risk of death. HES-induced bleeding complications may negatively affect outcome in patients with severe sepsis.
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Multicenter Study
Impaired long-term quality of life in survivors of severe sepsis : Chinese multicenter study over 6 years.
The present study was undertaken to evaluate the long-term health-related quality of life (HRQOL) as well as the employment status in survivors of severe sepsis up to 6 years afterwards. ⋯ The HRQOL in survivors of severe sepsis was impaired even up to 6 years after hospital discharge.
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Multicenter Study Clinical Trial
The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis.
Abnormal body temperatures (Tb) are frequently seen in patients with severe sepsis. However, the relationship between Tb abnormalities and the severity of disease is not clear. This study investigated the impact of Tb on disease severity and outcomes in patients with severe sepsis. ⋯ In patients with severe sepsis, hypothermia (Tb ≤ 36.5 °C) was associated with increased mortality and organ failure, irrespective of the presence of septic shock.