Articles: sepsis.
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Randomized Controlled Trial Multicenter Study Comparative Study
A multinational randomised study comparing didactic lectures with case scenario in a severe sepsis medical simulation course.
Medical simulation has been used to teach critical illness in a variety of settings. This study examined the effect of didactic lectures compared with simulated case scenario in a medical simulation course on the early management of severe sepsis. ⋯ A medical simulation course can improve resident physician knowledge in the early management of severe sepsis. Such a course should include a comprehensive curriculum that includes didactic lectures followed by simulation experience.
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Critical care medicine · Jul 2012
Multicenter StudyThe impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study*.
In sub-Saharan Africa, sepsis is an important cause of mortality. Optimal sepsis management including fluid resuscitation, early antibiotic administration, and patient monitoring is limited by lack of supplies and skilled health workers. ⋯ Early, monitored management of severely septic patients in Uganda improves survival and is feasible and safe even in a busy public referral hospital.
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Randomized Controlled Trial Multicenter Study Comparative Study
Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial.
Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination therapy comprising at least 2 antibiotics of different mechanisms remains controversial. ⋯ Among adult patients with severe sepsis, treatment with combined meropenem and moxifloxacin compared with meropenem alone did not result in less organ failure.
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Multicenter Study
[ECAIS study: inadvertent cardiovascular adverse events in sepsis].
To describe the incidence of cardiovascular adverse events in patients with sepsis in its various stages. ⋯ In this study patients with sepsis showed a low incidence of cardiovascular ischemic events. In contrast, arrhythmic events showed a high incidence. Conventional monitoring failed to detect any of the ischemic events and most arrhythmic events. In this study, cardiovascular events generated by adrenergic discharge had no impact upon mortality.
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Randomized Controlled Trial Multicenter Study Comparative Study
Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 130/0.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis: The CRYSTMAS study.
Inadequate initial treatment and delayed hemodynamic stabilization (HDS) may be associated with increased risk of death in severe sepsis patients. ⋯ NCT00464204.