Articles: sepsis.
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Intensive care medicine · Nov 2008
Multicenter StudyObesity is associated with increased morbidity but not mortality in critically ill patients.
To investigate the possible impact of obesity on morbidity and mortality in intensive care unit (ICU) patients included in the European observational sepsis occurrence in acutely ill patients (SOAP) study. ⋯ BMI did not have a significant impact on mortality in this mixed population of ICU patients.
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Am. J. Respir. Crit. Care Med. · Oct 2008
Multicenter StudyToll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.
Polymorphisms affecting Toll-like receptor (TLR)-mediated responses could predispose to excessive inflammation during an infection and contribute to an increased risk for poor outcomes in patients with sepsis. ⋯ Hypermorphic genetic variation in TLR1 is associated with increased susceptibility to organ dysfunction, death, and gram-positive infection in sepsis.
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Intensive care medicine · Sep 2008
Randomized Controlled Trial Multicenter StudyPolymyxin-B hemoperfusion inactivates circulating proapoptotic factors.
To test the hypothesis that extracorporeal therapy with polymyxin B (PMX-B) may prevent Gram-negative sepsis-induced acute renal failure (ARF) by reducing the activity of proapoptotic circulating factors. ⋯ Extracorporeal therapy with PMX-B reduces the proapoptotic activity of the plasma of septic patients on cultured renal cells. These data confirm the role of apoptosis in the development of sepsis-related ARF.
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Multicenter Study
Pulmonary vs nonpulmonary sepsis and mortality in acute lung injury.
Acute lung injury (ALI) is a frequent complication of sepsis. It is unclear if a pulmonary vs nonpulmonary source of sepsis affects mortality in patients with sepsis-induced ALI. ⋯ Although lower mortality was observed for ALI patients with a pulmonary vs nonpulmonary source of sepsis, this finding is likely due to a lower severity of illness in those with pulmonary sepsis. Pulmonary vs nonpulmonary source of sepsis was not independently predictive of mortality for patients with ALI.