Articles: sepsis.
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Intensive care medicine · Nov 2008
Multicenter StudyObesity is associated with increased morbidity but not mortality in critically ill patients.
To investigate the possible impact of obesity on morbidity and mortality in intensive care unit (ICU) patients included in the European observational sepsis occurrence in acutely ill patients (SOAP) study. ⋯ BMI did not have a significant impact on mortality in this mixed population of ICU patients.
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Am. J. Respir. Crit. Care Med. · Oct 2008
Multicenter StudyToll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.
Polymorphisms affecting Toll-like receptor (TLR)-mediated responses could predispose to excessive inflammation during an infection and contribute to an increased risk for poor outcomes in patients with sepsis. ⋯ Hypermorphic genetic variation in TLR1 is associated with increased susceptibility to organ dysfunction, death, and gram-positive infection in sepsis.
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Intensive care medicine · Sep 2008
Multicenter Study Comparative StudyDoes severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study.
To compare the time course of organ dysfunction/failure, mortality and cause of death in patients with severe sepsis (SS) and patients with severe non-infectious systemic inflammatory response syndrome (SNISIRS). ⋯ SIRS/sepsis: clinical studies.
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Intensive care medicine · Sep 2008
Multicenter StudyIncidence of and mortality due to sepsis, severe sepsis and septic shock in Italian Pediatric Intensive Care Units: a prospective national survey.
The objective was to assess the incidence of sepsis, severe sepsis and septic shock and their mortality in Italian Pediatric Intensive Care Units (PICUs). ⋯ The descriptor is pediatrics.
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Intensive care medicine · Sep 2008
Multicenter StudyCentral venous to mixed venous blood oxygen and lactate gradients are associated with outcome in critically ill patients.
Blood O(2) saturation and lactate concentration gradients from superior vena cava (SVC) to pulmonary artery (PA) occur in critically ill patients. These gradients (DeltaSO(2) and Delta[Lac]) may be positive or negative. We tested the hypothesis that positive DeltaSO(2) and Delta[Lac] are associated with improved survival in critically ill patients. ⋯ A strong association exists between positive DeltaSO(2) and Delta[Lac] and survival in critically ill patients. Whether therapy aimed at increasing DeltaSO(2) and Delta[Lac] results in improved ICU survival remains to be determined.