Articles: sepsis.
-
The Journal of pediatrics · Jul 1996
Multicenter StudyEarly-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network.
Early-onset sepsis (occurring within 72 hours of birth) is included in the differential diagnosis of most very low birth weight (VLBW) neonates. To determine the current incidence of early-onset sepsis, risk factors for disease, and the impact of early-onset sepsis on subsequent hospital course, we studied a cohort of 7861 VLBW neonates (401 to 1500 gm) admitted to the 12 National Institute of Child Health and Human Development (NICHD) Neonatal Research Network centers during a 32-month period (1991-1993). ⋯ Early-onset sepsis remains an important but uncommon problem among VLBW preterm infants. Improved diagnostic strategies are needed to enable the clinician to distinguish between the infected and the uninfected VLBW neonate with symptoms and to target continued antibiotic therapy to those who are truly infected.
-
Rev Med Chir Soc Med Nat Iasi · Jul 1996
Review[The current pathogenetic aspects of MODS in the sepsis patient].
MODS, a phenomenon observed in many critically ill patients, is the progressive failure of two or more organ system which results from nonspecific systemic responses to abnormal intravascular inflammation. It is triggered by a number of cellular humoral and biochemical mediators (more than 100). This article takes up the role of individual organ system dysfunction in the development of MODS. Cardiopulmonary, renal and hepatic responses to injury and infection and the relation of these responses to the subsequent development of MODS have been the subject of intense investigations; recently the gastrointestinal tract was identified as another target organ in such patients.