Articles: sepsis.
-
Editorial Review
Tumor necrosis factor in sepsis: mediator of multiple organ failure or essential part of host defense?
Tumor necrosis factor-alpha (TNF) exerts numerous influences which, in association with severe infection, subserve both detrimental as well as beneficial host responses. The current review addresses recent insights into the structure and function of this pleiotropic cytokine, with a particular emphasis upon cellular and organ system consequences of sepsis-induced TNF activity. A comparison of responses elicited by endotoxin or TNF administration are discussed as are mechanisms of endogenous TNF regulation, such as soluble receptors, anti-inflammatory cytokines, and counter-regulatory responses. A review of past and future clinical strategies for altering TNF activity during sepsis is also provided.
-
Rev Gastroenterol Peru · Jan 1995
Review Comparative Study[Intra-abdominal sepsis: surgical management].
Intraabdominal sepsis is a frequent clinical disorder in inpatients with severe consequences as septic shock and multisystem organic failure. It starts with the presence of germs or toxins from the abdominal cavity either intra or retroperitoneal. Pathophysiology is not yet totally understood. ⋯ Treatment is based in the administration of antibiotics, nutritional support, ventilatory and hemodynamic aids. The keystone of the management is surgery. This review details the main technics and strategies of the surgeon in the operative room.
-
To examine three typical disease states seen in intensive care, sepsis, Fulminant purpura and acute respiratory distress syndrome (ARDS) to assess the implication of cytokines in their pathogenesis and particularly in the clinical applications of possible cytokine inhibitors. ⋯ Future clinical strategies designed to combat. Future clinical strategies designed to fight against the most critical diseases in intensive care medicine require some use of any kind of immunotherapy. In animal studies, convincing data are available showing that immunotherapy improves the prognosis of sepsis, whereas in humans, to date, the results appear to be deceiving. Future research in this direction is mandatory, in sepsis and in other disease states, like ARDS, because no other hope for treating these patients seems to appear in a near future.