Articles: sepsis.
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Rev Gastroenterol Peru · Jan 1995
Review Comparative Study[Intra-abdominal sepsis: surgical management].
Intraabdominal sepsis is a frequent clinical disorder in inpatients with severe consequences as septic shock and multisystem organic failure. It starts with the presence of germs or toxins from the abdominal cavity either intra or retroperitoneal. Pathophysiology is not yet totally understood. ⋯ Treatment is based in the administration of antibiotics, nutritional support, ventilatory and hemodynamic aids. The keystone of the management is surgery. This review details the main technics and strategies of the surgeon in the operative room.
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Clinical and experimental evidence confirms that delivery of nutrients via the gastrointestinal tract reduces septic morbidity in critically injured patients. Early enteral feeding seems to maintain mucosal integrity and to support the gut as an important immunologic organ that may affect other areas of the body. There is increasing evidence to suggest that specific nutrients are especially beneficial in maintaining intestinal host-defense function in times of critical illness and injury.
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In part 2 author pays attention to new findings on treatment of sepsis and septic shock. He emphasizes facts which are of immediate importance for clinical practice and therapy. Possibilities of immunomodulating therapy (monoclonal antibodies, immunoglobulins) are described in detail.