Articles: chronic.
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Nonopioid analgesic drugs may interfere with platelet inhibition by aspirin. Recent in vitro and clinical studies in patients with cardiovascular disease have suggested that this pharmacodynamic interaction may also occur with dipyrone, a nonopioid analgesic popular in Europe, Asia and South America. ⋯ Dipyrone given for 5 days or longer blunts platelet inhibition by low-dose aspirin in the majority of recipients.
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A 61-year-old woman presented for outpatient evaluation of a 1-week history of fever and upper respiratory symptoms. She denied tobacco use, weight loss, hemoptysis, chronic cough, or recent travel and was in otherwise good health. ⋯ She denied any worsening hoarseness or any other vocal changes. She did report a positive family history of squamous cell lung cancer in her father.