Articles: function.
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Critical Care Posters IISESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Echocardiography is an important tool for evaluating cardiac and hemodynamic functions in small animals but requires sedation and immobility, which influences cardiac performance. Minimizing the hemodynamic effects of anesthesia is extremely important for improving applicability of animal models to the clinical setting, especially in models of shock. We aimed to evaluate the effects of isoflurane dose on myocardial function in a murine model, and to attempt to compare very low doses of isoflurane to a state in which the mice were off anesthesia. ⋯ The following authors have nothing to disclose: Fabien Picard, François Depret, Sergio Zanotti-Cavazzoni, Steven HollenbergNo Product/Research Disclosure Information.
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Am. J. Respir. Crit. Care Med. · Feb 2014
Persistent Effects of Maternal Smoking during Pregnancy on Lung Function and Asthma in Adolescents.
The extent to which maternal smoking in pregnancy (MSP) has persisting effects on respiratory health remains uncertain and the mechanisms involved are not fully understood. Alterations in immune function have been proposed as a mechanism contributing to respiratory disease. ⋯ MSP increases risk of asthma and wheezing in adolescence; mechanisms go beyond reducing lung function and exclude altering immune function or enhancing atopy.
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Am. J. Respir. Crit. Care Med. · Feb 2014
Deficiency of MDA5 Results in Exacerbated Chronic Post-Viral Lung Inflammation.
Respiratory viral infections can result in the establishment of chronic lung diseases. Understanding the early innate immune mechanisms that participate in the development of chronic postviral lung disease may reveal new targets for therapeutic intervention. The intracellular viral sensor protein melanoma differentiation-associated protein 5 (MDA5) sustains the acute immune response to Sendai virus, a mouse pathogen that causes chronic lung inflammation, but its role in the development of postviral chronic lung disease is unknown. ⋯ MDA5 modulates the development of chronic lung inflammation by regulating the early inflammatory response in the lung.
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Anasthesiol Intensivmed Notfallmed Schmerzther · Feb 2014
Review[Update glutamine and antioxidants in critically ill patients].
Critical illness leads to oxidative stress and can induce or exacerbate nutrient deficiencies. This predisposes patients in the intensive care unit to impaired immune function and increased risk of developing infectious complications, organ dysfunction, and therefore worsens clinical outcome. ⋯ The following article summarizes the rationale and provides an update on recent clinical studies with special focus on the use of glutamine and antioxidants in critically ill patients. It further provides recommendations for the clinical use of these substrates in this particular patient population.