Articles: sars-cov-2.
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During epidemics, the estimation of the effective reproduction number (ERN) associated with infectious disease is a challenging topic for policy development and medical resource management. The emergence of new viral variants is common in widespread pandemics including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A simple approach is required toward an appropriate and timely policy decision for understanding the potential ERN of new variants is required for policy revision. ⋯ The mobility-adjusted ERN of the Alpha variant was 15-30%, which was 20-40% higher than the original Wuhan strain in Osaka, Aichi, and London. Similarly, the mobility-adjusted ERN of the Delta variant was 20%-40% higher than that of the Wuhan strain in Osaka and Aichi. The proposed metric would be useful for the proper evaluation of the infectivity of different SARS-CoV-2 variants in terms of ERN as well as the design of the forecasting system.
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Chest radiographic scoring systems for COVID-19 pneumonia have been developed. However, little is published on the utilityof these scoring systems in low- and middle-income countries. ⋯ We have demonstrated the utility of the Brixia scoring system in a middle-income country setting and developed the first SArisk stratification models incorporating comorbidities and a serological marker. When used in conjunction with age, male gender, obesityand CRP, the Brixia scoring system is a promising and reliable risk stratification tool. This may help inform the clinical decision pathway inresource-limited settings like ours during future waves of COVID-19.
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Southern medical journal · Feb 2023
Case ReportsPublic Health Measures and SARS-CoV-2 Cases in the Juvenile Justice System: Implications for Pandemic Response in the Detention Setting.
The purpose of this study was to examine severe acute respiratory syndrome-coronavirus-2 case positivity in juvenile justice facilities of two different states alongside institutional, local, and state public health policies during the first 6 months of the coronavirus disease 2019 pandemic. ⋯ The Texas facility reported a higher percentage of community-acquired infections compared with California, coinciding with reopening measures in Texas. Texas also enacted a mask mandate later than California. These public health measures, among other factors, likely contributed to higher community rates in Texas, thereby affecting rates among the detained youth.
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Semin Respir Crit Care Med · Feb 2023
The Origins of Severe Acute Respiratory Syndrome-Coronavirus-2.
An outbreak of severe pneumonia of unknown cause was identified in Wuhan, China in December 2019: the causative agent was a novel betacoronavirus, severe acute respiratory syndrome-cotonavirus-2 (SARS-CoV-2), a virus that joins a list of coronaviruses causing severe (e.g., SARS and Middle East respiratory syndrome) or milder (e.g., 229E, OC43, NL63, and HKU1) respiratory tract infection. The World Health Organization (WHO) classified the spreading outbreak as a pandemic on March 11, 2020. Many SARS-related coronaviruses (SARSr-CoVs) have been identified in bats, particularly in Rhinolophus horseshoe bats, animals that are common in southern China and Southeast Asia. ⋯ Study of the origins of SARS-CoV-2 have been complicated by intense media and political commentary, features that may slow the studies required to understand the viral origins. Such studies are complex and may be slow: international openness and co-operation is vital. Origins explanations are needed to predict or prevent future pandemics and support the "One Health" approach to disease.
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Observational Study
A combined role for low vitamin D and low albumin circulating levels as strong predictors of worse outcome in COVID-19 patients.
We aimed to assess the combined role of vitamin D and albumin serum levels as predictors of COVID-19 disease progression. ⋯ The measurement of both vitamin D and serum albumin levels on COVID-19 patients' admission, and their combined evaluation, provides a simple prognostic tool that could be employed to guide prompt clinical decisions.