Articles: sars-cov-2.
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The SARS-CoV-2 coronavirus pandemic continues causing significant global morbidity and mortality. COVID-19 is an acute respiratory infection that can affect other organs. Tuberculosis (TB) is also an endemic infection that typically occurs with pulmonary involvement and very infrequently, with extra-pulmonary involvement. ⋯ The most frequently associated infection was due to human immunodeficiency virus, (n = 3), underweight (n = 2), COPD (n = 1) and drug addiction (n = 1). Three presented exclusive extrapulmonary involvement of the central nervous system, two pulmonary and pericardial. Four patients (80%) had a favorable evolution.
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The development of easy-to-perform diagnostic methods is highly important for detecting current coronavirus disease (COVID-19). This pilot study aimed at developing a lateral flow assay (LFA)-based test prototype to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in saliva samples. ⋯ The developed LFA assay demonstrated a potential of SARS-CoV-2 detection in saliva samples. Further technical assay improvements should be made to enhance diagnostic performance followed by a validation study in a larger cohort of both asymptomatic and symptomatic patients in the early stage of infection.