Articles: prospective-studies.
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The present review discusses the hemodynamic and immune-modulatory effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling upon data in hemorrhagic and septic shock. ⋯ A therapy that simultaneously blocks the damaging components of sepsis will have an impact on the management of sepsis. Proper designed prospective studies may prove a beneficial role for hypertonic saline solution in the future.
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J Cardiovasc Surg (Torino) · Feb 2015
Thoracic endovascular aortic repair or best medical therapy for uncomplicated type b aortic dissection? a meta-analysis.
To conduct a meta--analysis of all studies comparing thoracic endovascular aortic repair (TEVAR) and best medical therapy (BMT) for treating uncomplicated Type B aortic dissection (TBAD). ⋯ TEVAR did not provide obvious early survival advantage for uncomplicated TBAD over BMT, especially in the patients using TEVAR alone. It may remain a treatment option in uncomplicated TBAD patients with high risks for later complications. More randomized, prospective, long--term studies are needed to further clarify whether TEVAR could be a better first--line treatment strategy vs BMT for uncomplicated TBAD.