Articles: brain-pathology.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Prediction of recovery from post-traumatic vegetative state with cerebral magnetic-resonance imaging.
The early post-traumatic vegetative state (VS) is compatible with recovery. Various clinical and laboratory tests have failed to predict recovery so we assessed the value of cerebral magnetic-resonance imaging (MRI) in prediction of recovery. ⋯ Cerebral MRI findings in the subacute stage after head injury can predict the outcome of the post-traumatic VS. Corpus callosum and dorsolateral brainstem lesions are highly significant in predicting non-recovery.
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Neurological research · Jun 1998
Review Case ReportsCutaneous T-cell lymphoma with intracerebral and bilateral intraocular spread.
Brain metastasis from systemic or cutaneous lymphoma is infrequently encountered. We present a case report of cutaneous T-cell lymphoma (CTCL) that metastasized to the brain. ⋯ This report focuses attention on the typical presentation and markedly poor prognosis that characterize this rare problem. It also emphasizes the suspicion with which a brain mass in a lymphoma patient with neurological changes should be regarded.
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FEMS Immunol. Med. Microbiol. · Jun 1998
ReviewNeuropathological findings in new variant CJD and experimental transmission of BSE.
The diagnosis of new variant Creutzfeldt-Jakob disease is dependent on the neuropathological examination of brain tissue following brain biopsy or autopsy. The characteristic neuropathological features are multiple 'florid' plaques in the cerebral and cerebellar cortex, spongiform change most marked in the basal ganglia, severe thalamic gliosis and marked accumulation of the disease-associated prion protein in diffuse or pericellular deposits in the cerebrum and cerebellum. ⋯ This has given rise to the possibility that prion protein in new variant Creutzfeldt-Jakob disease might be transported to the brain by circulating lymphocytes in the blood. Experimental strain typing of new variant Creutzfeldt-Jakob disease has shown that the transmissible agent responsible for this disorder is identical to that identified in bovine spongiform encephalopathy, confirming the hypothesis that exposure to the bovine spongiform encephalopathy agent, presumably through the diet, is the cause of new variant Creutzfeldt-Jakob disease.
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We have previously shown that mild hypothermia applied after hypoxia-ischemia in newborn piglets and rats reduces brain injury evaluated 3-7 d after the insult. The aim of the present study was to assess the neuroprotective efficacy of hypothermia with respect to short- (neuropathology) and long-term (neuropathology and sensorimotor function) outcome after hypoxia-ischemia in 7-d-old rats. One hundred fourteen animals from 13 litters survived either 1 or 6 wk after a hypoxic-ischemic insult. ⋯ There was a significant correlation between sensorimotor performance and infarct volume (r = 0.66; p < 0.001). However, the sensorimotor function was not significantly improved by hypothermia if all animals were included, but in female pups the total functional score was higher in the hypothermia group (150 +/- 35 versus 100 +/- 34, p < 0.0007) which corresponded to a marked (51%) reduction of the neuropathology score in this subgroup. This is the first neonatal study to show a long-term histopathologic protection of the brain after posthypoxic hypothermia.