Articles: brain-pathology.
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AJR Am J Roentgenol · Nov 1997
Comparative StudyComparison of HASTE and segmented-HASTE sequences with a T2-weighted fast spin-echo sequence in the screening evaluation of the brain.
The purpose of this study was to evaluate the neuroradiologic application of half-Fourier acquisition single-shot turbo spin-echo (HASTE) and segmented-HASTE (s-HASTE) sequences in comparison with a T2-weighted fast spin-echo sequence. ⋯ The HASTE and s-HASTE sequences afford substantial time reduction and also decrease motion artifacts and thus have potential advantages for neuroradiologic application, especially in uncooperative or unsedated children. The s-HASTE sequence may be preferable to the HASTE sequence because of fewer blurring artifacts and higher T2 contrast. However, small hyperintense and hypointense lesions may be overlooked when HASTE and s-HASTE sequences are used.
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To assess the clinical utility of GRASE (gradient- and spin-echo) MR imaging of the brain by comparing it with the T2-weighted turbo spin-echo technique. ⋯ T2-weighted GRASE is a fast imaging technique with a potential for replacing turbo spin-echo in routine MR imaging of the brain. GRASE maintains the contrast resolution of turbo spin-echo imaging and is better at depicting lesions with paramagnetic susceptibility characteristics.
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AJNR Am J Neuroradiol · Oct 1997
Comparative StudyComparison of spin-echo MR pulse sequences for imaging of the brain.
To determine the value of the gradient- and spin-echo (GRASE) technique as compared with the fast spin-echo and conventional spin-echo techniques in MR imaging of the brain. ⋯ Fast spin-echo remains the standard technique in MR imaging of the brain. However, GRASE might be useful in special cases, such as with uncooperative patients whose conventional or fast spin-echo images show severe motion artifacts.
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J. Neuropathol. Exp. Neurol. · Oct 1997
Temporal and regional patterns of axonal damage following traumatic brain injury: a beta-amyloid precursor protein immunocytochemical study in rats.
Diffuse axonal injury (DAI) is an important consequence of human head trauma. This experimental investigation utilized the immunocytochemical visualization of beta-amyloid precursor protein (beta-APP) to document regional patterns of axonal injury after traumatic brain injury (TBI) and to determine the importance of injury severity on the magnitude of axonal damage. Rats underwent moderate (1.84-2.11 atm) or severe (2.38-2.52 atm) parasagittal fluid-percussion (F-P) brain injury or sham procedures. ⋯ At multiple periods after TBI, selective cortical and thalamic neurons displayed increased staining of the perikarya. A significant increase in the overall frequency of beta-APP profiles was documented in the severe vs moderately injured rats at 72 h after TBI. These data indicate that parasagittal F-P brain injury (a) results in widespread axonal damage, (b) that axonal damage includes both reversible and delayed patterns, and (c) that injury severity is an important factor in determining the severity of the axonal response to TBI.
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Comparative Study
Value of magnetization transfer contrast in intracranial enhancing and nonenhancing lesions with paramagnetic contrast agents.
To evaluate normal brain structures and various brain lesions by magnetic resonance (MR) imaging with magnetization transfer (MT) under the use of paramagnetic contrast agents. ⋯ The MTC method improves conspicuity and detection of intracranial enhancing lesions with use of paramagnetic contrast agents. Although the MTC method does not replace the conventional method, it is useful for detecting small enhancing lesions and for evaluating some nonenhancing lesions.