Articles: brain-pathology.
-
Wien Med Wochenschr · Jan 1996
[Magnetic resonance tomography of the brain in amyotrophic lateral sclerosis].
We compared the magnetic resonance imaging results of 15 patients suffering from amyotrophic lateral sclerosis (ALS) with those of 30 age-matched controls to search for disease specific cerebral abnormalities. Symmetric hyperintensity along the corticospinal tract on the proton density spin-echo sequence was exclusively found in 4 ALS patients. ⋯ Signal loss of the motor cortex on T2-weighted images was frequently seen in ALS (9 patients) but was also observed in controls. As MRI is capable of providing direct evidence for ALS besides excluding other diseases it should be included in the diagnostic work-up of these patients.
-
In this established outcome model of cardiac arrest in dogs, we have used total (summed regional) brain histopathologic damage scores. The present study describes the regional progression of necrotic (ischemic) neuron prevalence with increasing duration of cardiac arrest. It tests the hypothesis that increases in the total prevalence of necrotic neurons better correspond to increasing arrest duration and better correlate with neurological deficit than do any individual regional scores. ⋯ Compared with total (summed regional) necrotic neuron prevalence scores, increased regional prevalence scores for cerebellar granule neurons with increasing arrest duration were equally significant, and scores for the caudate nucleus had nearly the same correlation with individual clinical neurological deficit.
-
AJR Am J Roentgenol · Oct 1995
Comparative StudyMR imaging of the brain: comparison of gradient-echo and spin-echo pulse sequences.
Gradient-echo pulse sequences can reduce imaging time and decrease motion artifacts. If gradient-echo pulse sequences are shown to be comparable to spin-echo sequences in MR imaging of the brain, then gradient-echo imaging can be valuable for examining critically ill, anxious, or uncooperative patients and can increase patient throughput. The purpose of this study was to prospectively compare one fast multiplanar spoiled gradient-recalled acquisition in the steady state (GRASS) (FMPSPGR) sequence with one conventional T1-weighted spin-echo sequence to determine the reliability of the FMPSPGR sequence for detecting cerebral lesions. ⋯ The FMPSPGR sequence provides high-quality images with fewer vascular pulsation artifacts three to four times faster than the spin-echo sequence. The FMPSPGR sequence can reliably show intracranial lesions and can substitute for the T1-weighted spin-echo sequence in routine brain imaging.
-
AJNR Am J Neuroradiol · Oct 1995
Improved detection of enhancing and nonenhancing lesions of multiple sclerosis with magnetization transfer.
To determine whether magnetization transfer imaging can improve visibility of contrast enhancement of multiple sclerosis plaques. ⋯ Magnetization transfer improves the visibility of enhancing multiple sclerosis lesions, because they have a higher contrast-to-noise ratio than conventional postcontrast T1-weighted images. High signal intensity on both nonenhancing and enhancing lesions noted only on precontrast T1-weighted magnetization transfer suggests a lipid signal was unmasked. If magnetization transfer is used in multiple sclerosis patients, a precontrast magnetization transfer image is necessary.