Articles: acetaminophen.
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Randomized Controlled Trial Comparative Study
The effect on knee-joint load of instruction in analgesic use compared with neuromuscular exercise in patients with knee osteoarthritis: study protocol for a randomized, single-blind, controlled trial (the EXERPHARMA trial).
Knee osteoarthritis (OA) is a mechanically driven disease, and it is suggested that medial tibiofemoral knee-joint load increases with pharmacologic pain relief, indicating that pharmacologic pain relief may be positively associated with disease progression. Treatment modalities that can both relieve pain and reduce knee-joint load would be preferable. The knee-joint load is influenced by functional alignment of the trunk, pelvis, and lower-limb segments with respect to the knee, as well as the ground-reaction force generated during movement. Neuromuscular exercise can influence knee load and decrease knee pain. It includes exercises to improve balance, muscle activation, functional alignment, and functional knee stability. The primary objective of this randomized controlled trial (RCT) is to investigate the efficacy of a NEuroMuscular EXercise (NEMEX) therapy program, compared with optimized analgesics and antiinflammatory drug use, on the measures of knee-joint load in people with mild to moderate medial tibiofemoral knee osteoarthritis. ⋯ These findings will help determine whether 8 weeks of neuromuscular exercise is superior to optimized use of analgesics and antiinflammatory drugs regarding knee-joint load, pain and physical function in people with mild to moderate knee osteoarthritis.
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Randomized Controlled Trial Multicenter Study
Non-superiority of Kakkonto, a Japanese herbal medicine, to a representative multiple cold medicine with respect to anti-aggravation effects on the common cold: a randomized controlled trial.
Kakkonto, a Japanese herbal medicine, is frequently used to treat the common cold not only with a physician's prescription, but also in self-medication situations. This study aimed to examine whether Kakkonto prevents the aggravation of cold symptoms if taken at an early stage of illness compared with a well-selected Western-style multiple cold medicine. ⋯ Kakkonto did not significantly prevent the progression of cold symptoms, even when prescribed at an early stage of the disease.
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Gynecol. Obstet. Invest. · Jan 2014
Comparative Study Clinical TrialEstradiol and weight are covariates of paracetamol clearance in young women.
Paracetamol clearance differs between pregnant and non-pregnant women and between women with or without specific oral contraceptives (OCs). However, an association between female sex hormones and paracetamol clearance has never been explored. ⋯ Estradiol and weight in part explain the variation in paracetamol clearance in young women.
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Randomized Controlled Trial
The postoperative analgesic effect of morphine and paracetamol in the patients undergoing laparotomy, using PCA method.
postoperative pain increases the activity of the sympathetic system, causes hypermetabolic conditions, retains salt and water, increases glucose, fatty acid lactate and oxygen consumption, weakens the immunity system which delays wound healing. Our object was comparison of the analgesic effect of morphine and paracetamol in the patients undergoing laparotomy, using PCA method. ⋯ Morphine seems to be more effective at 2 and 4 hours, but after 4 hours they have similar effects, the satisfaction difference between both groups was not significant in the patients.
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Eur. J. Appl. Physiol. · Jan 2014
Randomized Controlled TrialThe influence of acetaminophen on repeated sprint cycling performance.
The aim of this study was to investigate the effect of acetaminophen on repeated sprint cycling performance. ⋯ Acetaminophen may have improved performance through the reduction of pain for a given work rate, thereby enabling participants to exercise closer to a true physiological limit. These results suggest that exercise may be regulated by pain perception, and that an increased pain tolerance can improve exercise performance.