Articles: acetaminophen.
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Clinical therapeutics · Sep 2013
ReviewDosing and antipyretic efficacy of oral acetaminophen in children.
A standardized approach to dosing acetaminophen in pediatric populations was published in 1983. That review proposed specific weight-related dosing for infants and children weighing 6 through 95 lb and an age-based schedule for children aged <4 months through 11 years. Subsequent clinical studies evaluating these and alternative doses of acetaminophen supported the recommended 10-15-mg/kg dose. ⋯ Data support the recommended 10-15-mg/kg oral dose and demonstrate that the age and weight schedules for over-the-counter acetaminophen proposed in 1983 remain appropriate.
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Int. J. Pediatr. Otorhinolaryngol. · Sep 2013
Randomized Controlled TrialEvaluation of the effect of aromatherapy with lavender essential oil on post-tonsillectomy pain in pediatric patients: a randomized controlled trial.
To evaluate the effect of aromatherapy with Lavandula angustifolia essential oil on post-tonsillectomy pain in pediatric patients. ⋯ Aromatherapy with lavender essential oil decreases the number of required analgesics following tonsillectomy in pediatric patients.
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Acta Neurol. Scand. · Sep 2013
Use of paracetamol in ischaemic stroke patients: evidence from VISTA.
Paracetamol is frequently prescribed for pain and fever control in acute stroke patients, but its effect on stroke outcome is unclear. The aim was to investigate the safety and benefit of paracetamol administration in the acute phase of ischaemic stroke. ⋯ This retrospective analysis is discouraging for prophylactic use of paracetamol in acute stroke patients, but underlines the need for a sufficiently powered randomized controlled trial.
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Am J Health Syst Pharm · Sep 2013
ReviewIntravenous acetylcysteine for indications other than acetaminophen overdose.
The use of intravenous acetylcysteine for off-label indications, specifically non-acetaminophen-induced acute liver failure (NAI-ALF), severe alcoholic hepatitis, and contrast-induced nephropathy (CIN), is reviewed. ⋯ Data regarding the use of i.v. acetylcysteine for the treatment of NAI-ALF and severe alcoholic hepatitis and in the prevention of CIN are inconclusive, though some evidence supports its use in certain populations.
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Clin Toxicol (Phila) · Sep 2013
Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose.
There is contention over whether reported dose correlates with toxicity in paracetamol poisoning and risk assessment is currently based on serum paracetamol concentration compared to a nomogram, irrespective of reported dose. Objective. To determine if reported dose predicts the need for N-acetylcysteine (NAC). ⋯ Reported dose was a good predictor of a toxic paracetamol concentration and SDAC reduced the probability of the concentration being above the nomogram. These predictions may assist in determining which patients could be started on NAC immediately.