Articles: acetaminophen.
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Comparative Study
A matched case control study with propensity score balancing examining the protective effect of paracetamol against parentally reported apnoea in infants.
Central apnoea occurs in infants and if not detected leads to death. Central apnoea is a prostaglandin E(2) (PGE2) mediated effect that is susceptible to pharmacologic manipulation in animal models. Paracetamol and ibuprofen are centrally and peripherally acting PGE2 inhibitors, respectively. ⋯ Prior paracetamol use was protective against apnoea in infants. We could not demonstrate an effect for ibuprofen.
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Studies have examined the association between acetaminophen (APAP) use and renal disease; however, their interpretation is limited by a number of methodological issues. ⋯ Acute prescription-acquired APAP use was associated with renal disease, while chronic use was not. Because this study assessed APAP use in pharmacy claims, further research accounting for over-the-counter APAP use is warranted before the safety of chronic APAP consumption can be firmly established.