Articles: acetaminophen.
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Randomized Controlled Trial Multicenter Study Comparative Study
Randomized controlled study of telcagepant plus ibuprofen or acetaminophen in migraine.
To evaluate the efficacy and tolerability of telcagepant when co-administered with ibuprofen or acetaminophen for the acute treatment of migraine. ⋯ The combination of telcagepant 280 mg with either ibuprofen 400 mg or acetaminophen 1000 mg did not show a statistically significant difference from telcagepant alone. Numerically greater treatment effects in the combination treatment groups over the telcagepant 280 mg monotherapy suggest that telcagepant combination treatments may merit further evaluation in studies powered to detect smaller additive benefits. (Clinicaltrials.gov; NCT00758836).
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Eur Arch Otorhinolaryngol · Apr 2011
Randomized Controlled Trial Comparative StudyRectal acetaminophen versus peritonsillar infiltration of bupivacaine for postoperative analgesia after adenotonsillectomy in children.
There are a wide range of analgesic methods used for postoperative pain control in children undergoing elective adenotonsillectomy and there are many cases in which the postoperative analgesic modalities have not been fully successful to treat pain effectively. The acute postoperative analgesic effects of peritonsillar bupivacaine infiltration compared with rectal acetaminophen suppositories in elective adenotonsillectomy have been compared here. The methods employed were a single blind randomized clinical trail where 110 cases were selected to enter the study. ⋯ Throat pain at rest, after swallowing, after taking fluid and after soft food and also, parents' and nurses satisfaction regarding patient analgesia were compared. The results stated that there was no difference between the two groups regarding throat pain at rest, after swallowing, after taking fluid and after soft food and also, parents' and nurses' satisfaction. We concluded that when considering the feasibility of rectal acetaminophen, the results of the study suggest it superior due to minimal risks compared with local peritonsillar administration of bupivacaine for elective adenotonsillectomy of children.
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Randomized Controlled Trial
A randomized study of the efficacy and safety of intravenous acetaminophen compared to oral acetaminophen for the treatment of fever.
The purpose of this study was to assess the safety and dynamics of the onset of antipyretic efficacy of intravenous (IV) acetaminophen versus oral (PO) acetaminophen in the treatment of endotoxin-induced fever. ⋯ A single dose of IV acetaminophen is as safe and effective in reducing endotoxin-induced fever as PO acetaminophen. IV acetaminophen may be useful where patients are unable to tolerate PO intake or when an earlier onset of action is desirable.
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J. Perianesth. Nurs. · Apr 2011
ReviewUse of intravenous acetaminophen in the treatment of postoperative pain.
Pain management is a crucial component in the care of the postoperative patient. Although there have been innovative advances in pain management and new analgesic modalities, a need still exists for safer and more tolerable analgesics for the management of pain in the postoperative setting. ⋯ Intravenous acetaminophen may help reduce the consumption of opioid analgesics and has a safety and tolerability profile comparable to placebo. This review will discuss the novel characteristics of intravenous acetaminophen that may make it an attractive choice for the management of acute pain in the postoperative period.