Articles: acetaminophen.
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Paed Child Healt Can · Jul 1998
Acetaminophen and ibuprofen in the management of fever and mild to moderate pain in children.
Acetaminophen has become the non-narcotic of choice for children because of concerns regarding the connection between acetylsalicylic acid exposure and Reye's syndrome. Ibuprofen, recently granted over-the-counter status for children over two years of age, offers another choice for treatment. The efficacy and safety of both drugs have been studied in numerous clinical trials. This paper reviews the published evidence about the efficacy and safety of acetaminophen and ibuprofen with regard to treating fever and mild to moderate pain in children.
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Arzneimittel Forsch · Jun 1998
Randomized Controlled Trial Comparative Study Clinical TrialComparison of the efficacy and tolerability of a paracetamol/codeine fixed-dose combination with tramadol in patients with refractory chronic back pain.
Fifty-five patients suffering from refractory chronic back pain took part in a double-blind, multiple-dose, randomised, cross-over study to compare the efficacy and tolerability of a fixed-dose capsule preparation containing 500 mg paracetamol (CAS 103-90-2) and 30 mg codeine phosphate 1/2 H2O (CAS 41444-62-6) (talvosilen forte, test preparation) with a reference capsule preparation containing 50 mg tramadol hydrochloride (CAS 22204-88-2), in a regimen of two capsules 8-hourly. There were two treatment periods of up to 7 days each. ⋯ The test preparation was at least as efficacious as the reference in the treatment of back pain (81% of patients experienced good or satisfactory pain relief). 81% of patients tolerated the test well compared to only 69% receiving the reference, as per protocol analysis. The results of this study suggest that the test product is at least as efficacious as tramadol in the treatment of patients with refractory chronic back pain, whilst being better tolerated.
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Randomized Controlled Trial Comparative Study Clinical Trial
Double blind randomized comparative evaluation of nimesulide and paracetamol as antipyretics.
To compare the efficacy and safety of nimesulide and paracetamol as antipyretic agents. ⋯ Nimesulide is more effective than paracetamol as an antipyretic agent and is safe for use in infants and children.
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Journal of hepatology · Jun 1998
Letter Case ReportsSevere idiosyncratic acute hepatic injury caused by paracetamol.