Articles: acetaminophen.
-
Ann Acad Med Stetin · Jan 1997
[The effect of exercise on the pharmacokinetics of acetaminophen and acetylsalicylic acid].
The influence of exercise on the pharmacokinetics of drugs is not sufficiently apparent. Therefore the purpose of my study was to evaluate the influence of standardized exercise on pharmacokinetics of acetaminophen and acetylsalicylic acid (ASA) and also to establish whether moderate (submaximal) exercise demands modification involving the doses of these drugs. That was studied in 20 healthy young (ranging in age 22-42 years) male subjects receiving acetaminophen or ASA, 1 g orally. ⋯ Therefore, there is no need for dose adjustment in patient who moderately exercises (50% VO2max). A little change in pharmacokinetics parameters of acetaminophen and ASA could arise due to some differences of its physical and chemical properties. Without further studies on this subject, the explanation of that finding remains very much speculative.
-
Anaesth Intensive Care · Dec 1996
Randomized Controlled Trial Clinical TrialAnalgesic efficacy of paracetamol in children using tonsillectomy as a pain model.
The analgesic efficacy of paracetamol was assessed in a prospective, randomized, double-blinded study of 100 children undergoing tonsillectomy with or without adenoidectomy. Fifty children were given paracetamol elixir 40 mg/kg 40 minutes preoperatively (Group A); the remaining 50 children were given an oral placebo 40 minutes preoperatively and paracetamol suppositories 40 mg/kg after induction of anaesthesia (Group B). Paracetamol was the only analgesic given and was given either orally or rectally in order to produce high variations in plasma paracetamol concentrations postoperatively. ⋯ The incidence of nausea and vomiting was the same in both groups (20%) during the 24 hour postoperative period. Plasma paracetamol concentrations of 0.066-0.132 mmol/l are known to reduce temperature; plasma paracetamol concentrations which provide analgesia are unknown. Children with plasma paracetamol concentrations above 0.07 mmol/l had superior analgesia to those with concentrations below this level (P < 0.05).