Articles: acetaminophen.
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J. Clin. Periodontol. · May 1983
Comparative StudyEfficacy of paracetamol in reducing post-operative pain after periodontal surgery.
In a double-blind, placebo-controlled study, the efficacy of 2 doses of paracetamol (500 and 1000 mg) was assessed in post-operative pain after periodontal flap surgery. Both doses of paracetamol provided greater analgesia than placebo, however, significant analgesia (P less than 0.05) was only noted in the early post-operative period. The analgesia from both doses of paracetamol did not differ significantly throughout the 3-day observation period, however, greater analgesia was attributable to 1000 mg paracetamol in the immediate post-operative period. The results from this study suggest that paracetamol is an effective analgesic for controlling post-operative pain after periodontal flap surgery, with 1000 mg dose being more effective than 500 mg immediately after surgery.
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Tidsskr. Nor. Laegeforen. · Feb 1983
Randomized Controlled Trial Comparative Study Clinical Trial[Effect of orphenadrine/paracetamol combination tablets (Norgesic) on myalgia. A double-blind comparative study using a placebo in general practice].
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Randomized Controlled Trial Clinical Trial
Effect of a combination of orphenadrine/paracetamol tablets ('Norgesic') on myalgia: a double-blind comparison with placebo in general practice.
The clinical efficacy and tolerability of a combination preparation ('Norgesic') of 35 mg orphenadrine plus 450 mg paracetamol was compared with that of placebo in a controlled double-blind, parallel group, 7-day study comprising 44 patients suffering from pain due to tension of the cervical and upper thoracic musculature. The patients were allocated at random into two homogeneous groups, stratified by sex and initial pain intensity. One group received the combination, the other placebo. ⋯ Despite the low dosage used, orphenadrine/paracetamol produced statistically significant pain relief from initial levels by and from the second day of the study. Comparison between the groups showed that the analgesic efficacy of the combination was significantly superior to that of placebo from the third day of treatment. These results confirm the efficacy of a combination of orphenadrine/paracetamol in patients suffering from myalgia nuchae.
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Randomized Controlled Trial Comparative Study Clinical Trial
A double-blind comparison in general practice of a combination tablet containing orphenadrine citrate and paracetamol ('Norgesic') with paracetamol alone.
A double-blind trial of a combination tablet containing orphenadrine and paracetamol, 'Norgesic', was carried out to assess the value of this product compared with paracetamol alone. All three symptomatic parameters which were measured: pain, spasm and impaired activity, showed a significantly quicker recovery when the combination product was used. Further studies are necessary to evaluate the combination product against orphenadrine citrate alone.
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Comparative Study Clinical Trial
Suppression of postoperative pain by preoperative administration of ibuprofen in comparison to placebo, acetaminophen, and acetaminophen plus codeine.
The analgesic effect of preoperatively administered ibuprofen was evaluated in 107 dental outpatients undergoing the removal of impacted third molars. Subjects were given 800 mg ibuprofen prior to the procedure and 400 mg ibuprofen 4 and 8 hours later. Comparison was made to groups receiving either placebo at all three doses, 600 mg acetaminophen administered on the same schedule, or preoperatively administered placebo followed by two doses of postoperatively administered 600 mg acetaminophen plus 60 mg codeine. ⋯ Ibuprofen also resulted in less postoperative pain than acetaminophen plus codeine following the second dose. Side effects were similar across drug treatments and placebo with the exception of greater reports of drowsiness following the opiate-analgesic combination. These findings indicate that pretreatment with a nonsteroidal antiinflammatory drug, such as ibuprofen, results in a suppression of postoperative pain when compared to standard therapy without an increase in side effects.