Articles: cations.
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J Clin Monit Comput · Apr 2020
Correction to: Mindray 3-directional NMT Module (a new generation "Tri-axial" neuromuscular monitor) versus the Relaxometer mechanomyograph and versus the TOF-Watch SX acceleromyograph.
In the original publication of the article, the article note "Ashraf A. Dahaba and Zhao Yang Xiao equally contributed to the study and are both first authors." was published incorrectly. The correct statement should read as "Ashraf A. Dahaba and Zhao Yang Xiao equally contributed to the study and are both first authors and are both co-corresponding authors."
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Cardiac alterations (hypertrophic/dilated cardiomyopathy, and rhythm alterations) are one of the major causes of mortality and morbidity in propionic acidemia (PA), caused by the deficiency of the mitochondrial enzyme propionyl-CoA carboxylase (PCC), involved in the catabolism of branched-chain amino acids, cholesterol, and odd-chain fatty acids. Impaired mitochondrial oxidative phosphorylation has been documented in heart biopsies of PA patients, as well as in the hypomorphic Pcca-/-(A138T) mouse model, in the latter correlating with increased oxidative damage and elevated expression of cardiac dysfunction biomarkers atrial and brain natriuretic peptides (ANP and BNP) and beta-myosin heavy chain (β-MHC). ⋯ In vitro studies in HL-1 cardiomyocytes indicate that propionate, the major toxic metabolite accumulating in the disease, triggers the increase in expression levels of miRNAs, BNP, and β-MHC, concomitant with an increase in reactive oxygen species. Our results highlight miRNAs and signaling alterations in the PCC-deficient heart which may contribute to the development of PA-associated cardiomyopathy and provide a basis to identify new targets for therapeutic intervention.
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Eur. J. Clin. Invest. · Mar 2020
Coronavirus disease 2019: the harms of exaggerated information and non-evidence-based measures.
The evolving coronavirus disease 2019 (COVID-19) pandemic1 is certainly cause for concern. Proper communication and optimal decision-making is an ongoing challenge, as data evolve. ⋯ This can lead to inappropriate actions. It is important to differentiate promptly the true epidemic from an epidemic of false claims and potentially harmful actions.