Articles: pain.
-
To determine the risk: benefit of paracetamol combined with caffeine in the short-term management of acute pain conditions. ⋯ Paracetamol/caffeine (1,000 mg/130 mg) is effective and safe for use in acute management of pain. The hepatotoxicity of overdoses of paracetamol results from its oxidative metabolism, caffeine does not produce any increase in oxidative metabolism of therapeutic concentrations of paracetamol.
-
Review Meta Analysis
Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review.
To compare the efficacy of oral sweet solutions to water or no treatment in infants aged 1-12 months during immunisation. ⋯ Infants aged 1-12 months administered sucrose or glucose before immunisation had moderately reduced incidence and duration of crying. Healthcare professionals should consider using sucrose or glucose before and during immunisation.
-
Cochrane Db Syst Rev · May 2010
Review Meta AnalysisSingle dose oral gabapentin for established acute postoperative pain in adults.
Gabapentin is an antiepileptic drug, also used in the treatment of neuropathic pain, which is the subject of a Cochrane review, currently under revision. Its efficacy in treating established acute postoperative pain has not been demonstrated. ⋯ Gabapentin 250 mg is statistically superior to placebo in the treatment of established acute postoperative pain, but the NNT of 11 for at least 50% pain relief over 6 hours with gabapentin 250 mg is of limited clinical value and inferior to commonly used analgesics. Gabapentin 250 mg is not clinically useful as a stand-alone analgesic in established acute postoperative pain, though this is probably the first demonstration of analgesic effect of an antiepileptic in established acute pain.
-
Osteoarthr. Cartil. · May 2010
Meta AnalysisDoes land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials.
To determine if clinical guidelines recommending therapeutic exercise for people with hip osteoarthritis (OA) are supported by rigorous scientific evidence. ⋯ Currently there is only silver level evidence (one small RCT) supporting the benefit of land-based therapeutic exercise for people with symptomatic hip OA in terms of reduced pain and improved physical function. The limited number and small sample size of the included RCTs restricts the confidence that can be attributed to these results.
-
Meta Analysis
Efficacy of intranasal fentanyl spray versus other opioids for breakthrough pain in cancer.
To compare the efficacy of intranasal fentanyl spray (INFS), oral transmucosal fentanyl citrate (OTFC), fentanyl buccal tablet (FBT) and oral morphine (OM) for the treatment of breakthrough cancer pain (BTCP). ⋯ Based on currently available evidence, INFS is expected to provide the greatest improvement in the treatment of BTCP. Due to its slow onset to effect OM cannot be considered an efficacious treatment for BTCP.