Articles: ninos.
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Randomized Controlled Trial Multicenter Study Comparative Study Pragmatic Clinical Trial
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: A Randomized Pragmatic Trial.
Poor medication adherence is common. Text messaging is increasingly used to change patient behavior but often not rigorously tested. ⋯ Text message reminders targeting patients who delay refilling their cardiovascular medications did not improve medication adherence based on pharmacy refill data or reduce clinical events at 12 months. Poor medication adherence may be due to multiple factors. Future interventions may need to be designed to address the multiple factors influencing adherence.
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Recent randomized controlled trials (RCTs) have investigated glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual or triple co-agonists for weight loss among adults with overweight or obesity and without diabetes. ⋯ None. (PROSPERO: CRD42024505558).
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With the increase in trials assessing comparative effectiveness of approved products and alternative care strategies, guidance is needed to ensure ethical oversight is fit for purpose for the risks, burdens, and constraints on choice this research presents. ⋯ Ethical oversight of clinical research must be fit for purpose-with greater oversight for studies with greater risks, uncertainties, and impacts on meaningful patient decisions-and more streamlined oversight for other types of research.
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Pol. Arch. Med. Wewn. · Jan 2025
Comparison of models predicting efficacy of radioiodine therapy in patients with differentiated thyroid cancer.
Differentiated thyroid cancer (DTC) is the most common type of endocrine malignancy, with rising incidence over recent decades. Despite a favorable prognosis, DTC management remains complex, often involving thyroidectomy followed by radioactive iodine (RAI) therapy. While RAI is crucial for patient outcomes, its efficacy varies, necessitating the identification of predictors for treatment response. ⋯ Our study underscores the utility of sTg as a single parameter for predicting RAI efficacy in DTC patients, with a defined cut-off value facilitating clinical decision-making. The inclusion of CLT status may further enhance predictive models. There is a need to advance personalized management approaches for DTC patients undergoing RAI therapy.