Articles: ninos.
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Targeted therapy is the key for improving overall survival while decreasing the undesirable adverse effects of cancer treatment. Patients who received matched targeted therapies showed dramatically improved overall survival (OS) and progression-free survival (PFS) compared to those without matched therapies. ⋯ The development of cutting-edge technologies, such as next-generation sequencing, has enabled us to identify more actionable targets. In this special issue of BMC Medicine, a collection of highly translational and clinical oncology papers presented a series of studies on targeted therapies for a variety of cancer types, aiming to bridge the gap between genomic testing and precision medicine and spark innovations on improving the efficacy of targeted therapies.
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NHS England is planning to abolish the long-standing 4-hour target for waits in emergency departments. The target has been criticised as an arbitrary management target that is unrelated to clinical outcomes, but waits much longer than 4 hours in the emergency department cause a notable increase in mortality for admitted patients, suggesting that the 4-hour target is clinically important and should not be abolished.
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Zulfiqar A. Bhutta discusses prevention and treatment strategies for optimization of community-based management of severe acute malnutrition in children.
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Beginning in 2017, policy changes impacting the U. S. Refugee Admissions Program (USRAP) led to dramatic cuts in U. ⋯ Such rebuilding is a necessary step in addressing the global refugee crisis and a potential life-saving intervention for many refugees, who suffer a range of threats and maladies. Many have chronic untreated medical issues and untold psychological trauma-physical and emotional wounds from years of persecution. They need-and deserve-our help.