Articles: ninos.
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Pol. Arch. Med. Wewn. · Feb 2025
Efficacy of selected scales in the assessment of impaired awareness of hypoglycemia in adults with type 1 diabetes.
Impaired awareness of hypoglycemia (IAH) increases the risk of severe hypoglycemia. Questionnaires may allow for easy identification of patients with IAH and facilitate appropriate intervention. ⋯ The HypoA-Q, with a 9-point cut-off, demonstrated the highest sensitivity for diagnosing IAH, and may be considered the most valuable screening tool for IAH detection.
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Randomized Controlled Trial Multicenter Study
Atrasentan in Patients with IgA Nephropathy.
Patients with IgA nephropathy and severe proteinuria have a high lifetime risk of kidney failure. The efficacy and safety of the selective endothelin type A receptor antagonist atrasentan in reducing proteinuria in patients with IgA nephropathy are incompletely understood. ⋯ In this prespecified interim analysis, atrasentan resulted in a significant and clinically meaningful reduction in proteinuria as compared with placebo in patients with IgA nephropathy. (Funded by Novartis; ALIGN ClinicalTrials.gov number, NCT04573478.).