Articles: ninos.
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Endostatin (ES) is an endogenous angiogenesis inhibitor. It is confirmed that ES has antitumor effects and plays a crucial part in regulating vascular smooth cells' proliferation. However, ES's effect on pulmonary hypertension (PH) is unclear. We aimed to determine the effect of ES on PH's pathogenesis. ⋯ The administration of ES may be a new treatment for PH and PA remodeling, associating with the down-regulation of VEGF production.
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Pol. Arch. Med. Wewn. · Apr 2021
Quality and methodology of clinical practice guidelines on antiviral pharmacotherapy for COVID-19 during the early phase of the pandemic.
Despite availability of reliable guidelines development methods, the risk of producing less reliable documents may be higher when the guidelines are developed rapidly. ⋯ Most guidelines or guidance documents published during the early phase of the COVID-19 pandemic were of poor quality, contained recommendations for the use of antiviral therapy for SARS-CoV-2 infection despite only very low quality of evidence available, and were not updated on a regular basis.
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The situation regarding COVID‑19 in Poland is rapidly evolving. Because of this, it is important to investigate COVID‑19 mortality and its predictors in one of the most densely populated regions of the country, Silesia Province. ⋯ The estimated in‑hospital fatality rate for COVID‑19 was 11.5%, which is lower than the average COVID‑19 fatality rate in other European countries. The risk of in‑hospital death was associated with sex, age, and the number of coexisting diseases, such as chronic cardiovascular and respiratory diseases.
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Pol. Arch. Med. Wewn. · Apr 2021
Exercise test in patients with asymptomatic aortic stenosis - clinically useful or not?
Aortic valve replacement (AVR) is recommended for symptomatic patients with severe aortic stenosis (AS). In asymptomatic AS (AAS), exercise testing (ET) is recommended; however, it remains controversial. ⋯ In patients with AAS, ET is safe; however, in our study group, the results were not cru‑ cial in making a decision to perform AVR. Patients treated with β‑blockers who did not achieve 85% of predicted maximal heart rate had a higher probability of AVR. The influence of the use of β‑blockers on the decision to perform AVR in this patient population warrants further revision.