Articles: ninos.
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Pol. Arch. Med. Wewn. · Jan 2025
Changes in the epidemiological situation of multidrug-resistant tuberculosis in Poland in 2018-2022.
The presented analysis was conducted against the backdrop of the global pandemic and the Russian-Ukrainian war. The conflict on Poland's eastern border raised concerns about potential deterioration of the epidemiological situation in Poland due to the influx of immigrants from countries with a high incidence of multidrug‑resistant (MDR) tuberculosis (TB) and the Beijing genotype. ⋯ The war in Ukraine caused a massive influx of immigrants to Poland, many of whom were infected with MDR and Beijing strains of TB. There is a significant risk of an increase in the incidence of MDR‑TB in Poland in the future, as well as a potential for TB transmission between the immigrants and the native population.
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High occupational stress is generally associated with poorer mental health and reduced performance in military personnel, whereas access to support resources is associated with positive outcomes. However, little research has examined the unique stressors and supports experienced by sailors on ships while underway at sea. The objectives of this study were to (1) identify sailors' underway stressors and supports and (2) examine how these differ as a function of demographic and operational factors. ⋯ Sailors experience many stressors while underway. Increasing the resources available to underway sailors may be warranted, especially for female and enlisted personnel. Additional research is necessary to develop targeted interventions and resources. Possible recommendations include noise mitigation, berthing area improvements, sleep and/or scheduling interventions, improved access to mental and physical health care, and interventions to reduce the stigma associated with seeking mental health care.
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Randomized Controlled Trial Multicenter Study
CRISPR-Based Therapy for Hereditary Angioedema.
Hereditary angioedema is a rare genetic disease characterized by severe and unpredictable swelling attacks. NTLA-2002 is an in vivo gene-editing therapy that is based on clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9. NTLA-2002 targets the gene encoding kallikrein B1 (KLKB1). A single dose of NTLA-2002 may provide lifelong control of angioedema attacks. ⋯ NTLA-2002 administered in a single dose of 25 mg or 50 mg reduced angioedema attacks and led to robust and sustained reduction in total plasma kallikrein levels in patients with hereditary angioedema. These results support continued investigation in a larger phase 3 trial. (Funded by Intellia Therapeutics; ClinicalTrials.gov number, NCT05120830; EudraCT number, 2021-001693-33.).
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The dearth of research investigating the efficacy of virtual Army Combat Fitness Test (ACFT) training programs among female populations necessitates further exploration. This study aims to evaluate the effectiveness of a 12-week ACFT virtual exercise program among female participants. ⋯ Following the intervention, female participants experienced a significant increase of approximately 7% in their overall ACFT scores, with upward trends observed across all 6 individual ACFT events. These findings suggest that 12-week virtual suspension training can be a valuable tool for enhancing physical fitness and performance among female participants, particularly within the context of military readiness.