Articles: ninos.
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Pol. Arch. Med. Wewn. · Jan 2025
Prognostic significance of anti-gliadin and anti-F-actin IgA antibodies in primary sclerosing cholangitis.
Primary sclerosing cholangitis (PSC) is a biliary disorder associated with a high risk of end‑stage liver disease and cholangiocarcinoma (CCA). Currently, prediction of unfavorable outcomes is hindered by a lack of valuable prognostic biomarkers. ⋯ Anti‑gliadin and anti‑F‑actin IgA identify the subgroup of PSC patients with a more severe disease and at a risk of shortened transplantation‑free survival.
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Triple-negative breast cancer is an aggressive subtype with a high incidence in young patients, a high incidence in non-Hispanic Black women, and a high risk of progression to metastatic cancer, a devastating sequela with a 12- to 18-month life expectancy. Until recently, one strategy for treating early-stage triple-negative breast cancer was chemotherapy after surgery. However, it was not known whether the addition of immune therapy to postsurgery chemotherapy would be beneficial. ⋯ The addition of the immune therapy drug atezolizumab to chemotherapy after surgery did not provide benefit among patients with triple-negative breast cancer who are at high risk of recurrent disease.
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Pol. Arch. Med. Wewn. · Jan 2025
Application of the TRI-SCORE to predict long-term mortality in acute heart failure patients with moderate-severe tricuspid regurgitation.
Moderate‑to‑severe tricuspid regurgitation (TR) in the setting of acute heart failure (AHF) has been found to be associated with worse clinical outcomes. Recently, the TRI‑SCORE model was developed to predict clinical outcomes after isolated tricuspid surgery. ⋯ The AHF patients with moderate‑to‑severe TR have a poor prognosis during follow‑up. TRI‑SCORE can predict all‑cause mortality in these patients.