Articles: ninos.
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Randomized Controlled Trial Multicenter Study Comparative Study
Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma.
Muscle-invasive urothelial carcinoma is an aggressive disease with high rates of relapse. Whether pembrolizumab as adjuvant therapy would be effective in patients with high-risk muscle-invasive urothelial carcinoma after radical surgery is unknown. ⋯ Among patients with high-risk muscle-invasive urothelial carcinoma after radical surgery, disease-free survival was significantly longer with adjuvant pembrolizumab than with observation. (Funded by the National Cancer Institute of the National Institutes of Health and others; Alliance A031501 AMBASSADOR ClinicalTrials.gov number, NCT03244384.).
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Randomized Controlled Trial
In subclinical AF, apixaban vs. aspirin reduced stroke or systemic embolism at 3.5 y, regardless of duration of recent subclinical AF episodes.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
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Mayo Clinic proceedings · Jan 2025
Randomized Controlled TrialFactors Associated With Enrollment to a Decentralized Study.
To assess whether the mode and formatting of invitations affect enrollment in a large, decentralized study. ⋯ Invitations via EHR rather than email facilitate enrollment to large, decentralized studies. Enhanced display of invitation material did not increase enrollment. Lower enrollment rates in men, younger individuals, non-White and Hispanic individuals, and rural residents highlight a continued need to focus enrollment strategies on these subgroups.
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Randomized Controlled Trial
In HF with mildly reduced or preserved ejection fraction, finerenone reduced worsening HF or CV death at 32 mo.
GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].
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Randomized Controlled Trial Multicenter Study
In insulin-naive T2D, weekly efsitora was noninferior to daily degludec for reducing HbA1c at 52 wk.
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].