Articles: diagnosis.
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Multicenter Study
Diagnostic performance of S100B protein serum measurement in detecting intracranial injury in children with mild head trauma.
To assess the accuracy of S100B serum level to detect intracranial injury in children with mild traumatic brain injury. ⋯ S100B has an excellent sensitivity but poor specificity. It is therefore an accurate tool to help rule out an intracranial injury but cannot be used as the sole marker owing to its specificity. Used with clinical decision rules, S100B may help to reduce the number of unnecessary CT scans.
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Multicenter Study
Serial sampling of copeptin levels improves diagnosis and risk stratification in patients presenting with chest pain: results from the CHOPIN trial.
Copeptin has demonstrated a role in early rule out for acute myocardial infarction (AMI) in combination with a negative troponin. However, management of patients with chest pain with a positive copeptin in the setting of a negative troponin is unclear. ⋯ Patients with chest pain with an initial negative troponin but positive copeptin are common and carry an intermediate risk of AMI. A second copeptin drawn 2 h after presentation may help risk stratify and potentially rule out AMI in this cohort.
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Multicenter Study
Effect of age on survival in patients undergoing resection of hepatocellular carcinoma.
The benefit of surgical intervention for cancer should be estimated in relation to the life expectancy of the general population. The aim of this study was to provide a measure of relative survival after hepatectomy for hepatocellular carcinoma (HCC). ⋯ Although survival after liver resection for HCC is shortest in elderly patients, relative survival estimates suggest that hepatectomy can be of benefit in these patients, with a small loss of the entire individual lifespan.
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Korean J. Intern. Med. · Jan 2016
Multicenter StudyFeasibility of α-fetoprotein as a diagnostic tool for hepatocellular carcinoma in Korea.
The aim of this study was to evaluate the feasibility of α-fetoprotein (AFP) as a diagnostic tool for hepatocellular carcinoma (HCC) in Korean patients. ⋯ The cut-off AFP value for early-stage HCC was 17.4 ng/mL. Our study cautiously suggests that AFP has a role in the diagnosis of HCC, and that the appropriate value of AFP for the diagnosis of HCC may be 100 ng/mL rather than 200 ng/mL.
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The Journal of pediatrics · Dec 2015
Multicenter StudyIdentifying Pediatric Severe Sepsis and Septic Shock: Accuracy of Diagnosis Codes.
To evaluate accuracy of 2 established administrative methods of identifying children with sepsis using a medical record review reference standard. ⋯ Sepsis specific International Classification of Diseases, Ninth Revision, Clinical Modification codes identify pediatric patients with severe sepsis in administrative data more accurately than a combination of codes for infection plus organ dysfunction.